Archiv

2010

Heiseke A, Aguib Y, Schatzl HM
Autophagy, prion infection and their mutual interactions.
Curr Issues Mol Biol. 2010; 12(2) : 87-97

Backes S, Sperling KM, Zwilling J, Gasteiger G, Ludwig H, Kremmer E, Schwantes A, Staib C, Sutter G
Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation facto
J Gen Virol. 2010; 91(Pt 2) : 470-82

Di Lullo G, Soprana E, Panigada M, Palini A, Agresti A, Comunian C, Milani A, Capua I, Erfle V, Siccardi AG
The combination of marker gene swapping and fluorescence-activated cell sorting improves the efficiency of recombinant modified vaccinia virus Ankara vaccine production for human use.
J Virol Methods. 2010; 163(2) : 195-204

Hoffmann D, Wolfarth B, Hörterer HG, Halle M, Reichhuber C, Nadas K, Tora C, Erfle V, Protzer U, Schätzl HM
Elevated Epstein-Barr virus loads and lower antibody titers in competitive athletes.
J Med Virol. 2010; 82(3) : 446-51

Sarrazin C, Berg T, Ross RS, Schirmacher P, Wedemeyer H, Neumann U, Schmidt HH, Spengler U, Wirth S, Kessler HH, Peck-Radosavljevic M, Ferenci P, Vogel W, Moradpour D, Heim M, Cornberg M, Protzer U, Manns MP, Fleig WE, Dollinger MM, Zeuzem S
Prophylaxis, Diagnosis and Therapy of Hepatitis C Virus (HCV) Infection: The German Guidelines on the Management of HCV Infection.
Z Gastroenterol. 2010; 48(2) : 289-351

Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.
Future Microbiol. 2010; 5 : 221-39

Levin A, Hayouka Z, Friedler A, Brack-Werner R, Volsky DJ, Loyter A
A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.
J Gen Virol. 2010; 91(Pt 6) : 1503-13

Kimura T, Ishikawa K, Sakasegawa Y, Teruya K, Sata T, Schätzl H, Doh-Ura K
GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.
FEBS Lett. 2010; 584(6) : 1193-8

Lucifora J, Vincent IE, Berthillon P, Dupinay T, Michelet M, Protzer U, Zoulim F, Durantel D, Trepo C, Chemin I
Hepatitis B virus replication in primary macaque hepatocytes: crossing the species barrier toward a new small primate model.
Hepatology. 2010; 51(6) : 1954-60

Ga?per?i? J, Hafner-Bratkovi? I, Stephan M, Verani? P, Ben?ina M, Vorberg I, Jerala R
Tetracysteine-tagged prion protein allows discrimination between the native and converted forms.
FEBS J. 2010;

Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrant K, Protzer U, Knolle PA
Bioluminescence imaging allows measuring CD8 T cell function in the liver.
Hepatology. 2010; 51(4) : 1430-7

Hoffmann D, Seebach J, Foley BT, Frösner G, Nadas K, Protzer U, Schätzl HM
Isolated norovirus GII.7 strain within an extended GII.4 outbreak.
J Med Virol. 2010; 82(6) : 1058-64

John von Freyend M, Untergasser A, Arzberger S, Oberwinkler H, Drebber U, Schirmacher P, Protzer U
Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B.
J Viral Hepat. 2010;

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.
J Biol Chem. 2010; 285(9) : 6198-207

Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A
Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.
AIDS Res Ther. 2010; 7 : 20

Kutscher S, Allgayer S, Dembek CJ, Bogner JR, Protzer U, Goebel FD, Erfle V, Cosma A
MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays.
Gene Ther. 2010;

Riddell SR, Protzer U
Carving the CAR.
Gene Ther. 2010;

Marquardt JU, Quasdorff M, Varnholt H, Curth HM, Mesghenna S, Protzer U, Goeser T, Nierhoff D
Neighbor of punc E11, a novel oncofetal marker for hepatocellular carcinoma.
Int J Cancer. 2010;

Quasdorff M, Protzer U
Control of hepatitis B virus at the level of transcription.
J Viral Hepat. 2010; 17(8) : 527-36

Arzberger S, Hösel M, Protzer U
Apoptosis of hepatitis B virus-infected hepatocytes prevents release of infectious virus.
J Virol. 2010; 84(22) : 11994-2001

Nörder M, Becker PD, Drexler I, Link C, Erfle V, Guzmán CA
Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model.
PLoS ONE. 2010; 5(6) : e11400

Vincendeau M, Kramer S, Hadian K, Rothenaigner I, Bell J, Hauck SM, Bickel C, Nagel D, Kremmer E, Werner T, Leib-Mösch C, Brack-Werner R
Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).
AIDS. 2010;

Levin A, Hayouka Z, Helfer M, Brack-Werner R, Friedler A, Loyter A
Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein.
Biopolymers. 2010; 93(8) : 740-51

Meggendorfer M, Weierich C, Wolff H, Brack-Werner R, Cremer T
Functional nuclear topography of transcriptionally inducible extra-chromosomal transgene clusters.
Chromosome Res. 2010; 18(4) : 401-17

Meyer NH, Tripsianes K, Vincendeau M, Madl T, Kateb F, Brack-Werner R, Sattler M
Structural basis for homodimerization of the Src-associated during mitosis, 68-kDa protein (Sam68) Qua1 domain.
J Biol Chem. 2010; 285(37) : 28893-901

Roffé M, Beraldo FH, Bester R, Nunziante M, Bach C, Mancini G, Gilch S, Vorberg I, Castilho BA, Martins VR, Hajj GN
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Proc Natl Acad Sci U S A. 2010; 107(29) : 13147-52

Kremb S, Helfer M, Heller W, Hoffmann D, Wolff H, Kleinschmidt A, Cepok S, Hemmer B, Durner J, Brack-Werner R
EASY-HIT: HIV full-replication technology for broad discovery of multiple classes of HIV inhibitors.
Antimicrob Agents Chemother. 2010;

Drexler JF, Gloza-Rausch F, Glende J, Corman VM, Muth D, Goettsche M, Seebens A, Niedrig M, Pfefferle S, Yordanov S, Zhelyazkov L, Hermanns U, Vallo P, Lukashev A, Müller MA, Deng H, Herrler G, Drosten C
Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences.
J Virol. 2010; 84(21) : 11336-49

Leib MS, Larson MM, Panciera DL, Troy GC, Monroe WE, Rossmeisl JH, Forrester SD, Herring ES
Diagnostic utility of abdominal ultrasonography in dogs with chronic vomiting.
J Vet Intern Med. 2010; 24(4) : 803-8

Bauer T, Möllmann H, Weidinger F, Zeymer U, Seabra-Gomes R, Eberli F, Serruys P, Vahanian A, Silber S, Wijns W, Hochadel M, Nef HM, Hamm CW, Marco J, Gitt AK
Use of platelet glycoprotein IIb/IIIa inhibitors in diabetics undergoing PCI for non-ST-segment elevation acute coronary syndromes: impact of clinical status and procedural characteristics.
Clin Res Cardiol. 2010; 99(6) : 375-83

Bauer T, Gitt AK, Jünger C, Zahn R, Koeth O, Towae F, Schwarz AK, Bestehorn K, Senges J, Zeymer U, Acute Coronary Syndromes Registry (ACOS) investigators
Guideline-recommended secondary prevention drug therapy after acute myocardial infarction: predictors and outcomes of nonadherence.
Eur J Cardiovasc Prev Rehabil. 2010; 17(5) : 576-81

Bauer T, Stark T, Hofmann T, Ehling-Schulz M
Development of a stable isotope dilution analysis for the quantification of the Bacillus cereus toxin cereulide in foods.
J Agric Food Chem. 2010; 58(3) : 1420-8

2009

von Laer D, Baum C, Protzer U
Antiviral gene therapy.
Handb Exp Pharmacol. 2009; (189) : 265-97

Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hepatology. 2009; 50(6) : 1773-82

Stahl S, Sacher T, Bechtold A, Protzer U, Ganss R, Hämmerling GJ, Arnold B, Garbi N
Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma.
Immunol Lett. 2009; 123(1) : 31-7

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, John von Freyend M, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Bruning JC
Hepatic Bax-inhibitor (BI)-1 inhibits IRE1{alpha} and protects from obesity-associated insulin resistance and glucose intolerance.
J Biol Chem. 2009;

Gilch S, Schätzl HM
Aptamers against prion proteins and prions.
Cell Mol Life Sci. 2009; 66(15) : 2445-55

Gilch S, Bach C, Lutzny G, Vorberg I, Schätzl HM
Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation.
Cell Mol Life Sci. 2009;

Heiseke A, Aguib Y, Schatzl HM
Autophagy, Prion Infection and their Mutual Interactions.
Curr Issues Mol Biol. 2009; 12(2) : 87-98

Bach C, Gilch S, Rost R, Greenwood AD, Horsch M, Hajj GN, Brodesser S, Facius A, Schädler S, Sandhoff K, Beckers J, Leib-Mösch C, Schätzl HM, Vorberg I
Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.
J Biol Chem. 2009; 284(45) : 31260-9

Krammer C, Schätzl HM, Vorberg I
Prion-like propagation of cytosolic protein aggregates-insights from cell culture models.
Prion. 2009; 3(4)

Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J
Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Dev Cell. 2009; 16(1) : 35-46

Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, Voehringer D
Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.
J Exp Med. 2009; 206(3) : 549-59

Kastenmuller W, Gasteiger G, Stross L, Busch DH, Drexler I
Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens.
J Immunol. 2009; 182(5) : 2573-7

Huster KM, Stemberger C, Gasteiger G, Kastenmüller W, Drexler I, Busch DH
Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.
J Immunol. 2009; 183(11) : 6898-902

Backes S, Sperling KM, Zwilling J, Gasteiger G, Ludwig H, Kremmer E, Schwantes A, Staib C, Sutter G
Viral host range factors C7 or K1 are essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit PKR-mediated eIF2{alpha} phosphorylation.
J Gen Virol. 2009;

Di Lullo G, Soprana E, Panigada M, Palini A, Agresti A, Comunian C, Milani A, Capua I, Erfle V, Siccardi AG
The combination of marker gene swapping and fluorescence-activated cell sorting improves the efficiency of recombinant modified vaccinia virus Ankara vaccine production for human use.
J Virol Methods. 2009;

Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O’Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D
Unsung hero Robert C. Gallo.
Science. 2009; 323(5911) : 206-7

Krönig H, Hofer K, Conrad H, Guilaume P, Müller J, Schiemann M, Lennerz V, Cosma A, Peschel C, Busch DH, Romero P, Bernhard H
Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity.
Int J Cancer. 2009; 125(3) : 649-55

Di Bonito P, Grasso F, Mochi S, Petrone L, Fanales-Belasio E, Mei A, Cesolini A, Laconi G, Conrad H, Bernhard H, Dembek CJ, Cosma A, Santini SM, Lapenta C, Donati S, Muratori C, Giorgi C, Federico M
Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 protein.
Virology. 2009; 395(1) : 45-55

Hadian K, Vincendeau M, Mäusbacher N, Nagel D, Hauck SM, Ueffing M, Loyter A, Werner T, Wolff H, Brack-Werner R
Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.
J Biol Chem. 2009; 284(48) : 33384-91

Levin A, Hayouka Z, Helfer M, Brack-Werner R, Friedler A, Loyter A
Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.
PLoS ONE. 2009; 4(1) : e4155

Levin A, Hayouka Z, Brack-Werner R, Volsky DJ, Friedler A, Loyter A
Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration.
Protein Eng Des Sel. 2009; 22(12) : 753-63

Pairan A, Bruss V
Functional surfaces of the hepatitis B virus capsid.
J Virol. 2009; 83(22) : 11616-23

Lehmann MH, Kastenmuller W, Kandemir JD, Brandt F, Suezer Y, Sutter G
Modified vaccinia virus ankara triggers chemotaxis of monocytes and early respiratory immigration of leukocytes by induction of CCL2 expression.
J Virol. 2009; 83(6) : 2540-52

Schön U, Diem O, Leitner L, Günzburg WH, Mager DL, Salmons B, Leib-Mösch C
Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors.
J Virol. 2009; 83(23) : 12643-50

Krammer C, Kryndushkin D, Suhre MH, Kremmer E, Hofmann A, Pfeifer A, Scheibel T, Wickner RB, Schätzl HM, Vorberg I
The yeast Sup35NM domain propagates as a prion in mammalian cells.
Proc Natl Acad Sci U S A. 2009; 106(2) : 462-7

Aguib Y, Heiseke A, Gilch S, Riemer C, Baier M, Schätzl HM, Ertmer A
Autophagy induction by trehalose counteracts cellular prion infection.
Autophagy. 2009; 5(3) : 361-9

Schätzl HM
Drug targets in prion diseases.
Infect Disord Drug Targets. 2009; 9(1) : 1-2

Heiseke A, Aguib Y, Riemer C, Baier M, Schätzl HM
Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy.
J Neurochem. 2009; 109(1) : 25-34

Krammer C, Vorberg I, Schätzl HM, Gilch S
Therapy in prion diseases: from molecular and cellular biology to therapeutic targets.
Infect Disord Drug Targets. 2009; 9(1) : 3-14

Geissen M, Mella H, Saalmüller A, Eiden M, Proft J, Pfaff E, Schätzl HM, Groschup MH
Inhibition of prion amplification by expression of dominant inhibitory mutants–a systematic insertion mutagenesis study.
Infect Disord Drug Targets. 2009; 9(1) : 40-7

Op den Brouw ML, Binda RS, van Roosmalen MH, Protzer U, Janssen HL, van der Molen RG, Woltman AM
Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus.
Immunology. 2009; 126(2) : 280-9

Rothenaigner I, Kramer S, Meggendorfer M, Rethwilm A, Brack-Werner R
Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression.
Gene Ther. 2009; 16(3) : 349-58

Di Lullo G, Soprana E, Panigada M, Palini A, Erfle V, Staib C, Sutter G, Siccardi AG
Marker gene swapping facilitates recombinant Modified Vaccinia Virus Ankara production by host-range selection.
J Virol Methods. 2009; 156(1-2) : 37-43

2008

Quasdorff M, Hösel M, Odenthal M, Zedler U, Bohne F, Gripon P, Dienes HP, Drebber U, Stippel D, Goeser T, Protzer U.
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation.
Cell Microbiol. 2008;10(7):1478-90.

Op den Brouw ML, Binda RS, van Roosmalen MH, Protzer U, Janssen HL, van der Molen RG, Woltman AM.
Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus.
Immunology. 2008; 28.

Jenke AC, Wilhelm AD, Orth V, Lipps HJ, Protzer U, Wirth S.
Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.
Antimicrob Agents Chemother. 2008;52(7):2355-9.

Gilch S, Krammer C, Schätzl HM.
Targeting prion proteins in neurodegenerative disease.
Expert Opin Biol Ther. 2008;8(7):923-40.

Caetano FA, Lopes MH, Hajj GN, Machado CF, Pinto Arantes C, Magalhães AC, Vieira Mde P, Américo TA, Massensini AR, Priola SA, Vorberg I, Gomez MV, Linden R, Prado VF, Martins VR, Prado MA.
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.
J Neurosci. 2008;28(26):6691-702.

Hoffmann D, Seebach J, Cosma A, Goebel FD, Strimmer K, Schätzl HM, Erfle V
Therapeutic vaccination reduces HIV sequence variability.
FASEB J. 2008;22(2): 437-44

Krammer C, Suhre MH, Kremmer E, Diemer C, Hess S, Schätzl HM, Scheibel T, Vorberg I
Prion protein/protein interactions: fusion with yeast Sup35p-NM modulates cytosolic PrP aggregation in mammalian cells.
FASEB J. 2008;22(3): 762-73

Bohne F, Chmielewski M, Ebert G, Wiegmann K, Kürschner T, Schulze A, Urban S, Krönke M, Abken H, Protzer U
T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.
Gastroenterology. 2008;134(1): 239-47

Diemer C, Schneider M, Seebach J, Quaas J, Frösner G, Schätzl HM, Gilch S
Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection.
J Mol Biol. 2008;376(1): 23-34

Aguib Y, Gilch S, Krammer C, Ertmer A, Groschup MH, Schätzl HM
Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrP(c).
Mol Cell Neurosci. 2008;38(1):98-109.

Heiseke A, Schöbel S, Lichtenthaler SF, Vorberg I, Groschup MH, Kretzschmar H, Schätzl HM, Nunziante M
The novel sorting nexin SNX33 interferes with cellular PrP(Sc) formation by modulation of PrP(c) shedding.
Traffic. 2008;9(7):1116-29.

Gudima S, He Y, Chai N, Bruss V, Urban S, Mason W, Taylor J
Primary human hepatocytes are susceptible to infection by hepatitis delta virus assembled with envelope proteins of woodchuck hepatitis virus.
J Virol. (2008);82(15):7276-83.

Bleifuss, E., Bendz, H., Sirch, B., Thompson, S., Brandl, A., Milani, V., Graner, M. W., Drexler, I., Kuppner, M., Katsanis, E., Noessner, E., and Issels, R. D.
Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens.
Int J Hyperthermia. 2008 Jun 20:1-15.

2007

Cosma A, Nagaraj R, Staib C, Diemer C, Wopfner F, Schätzl H, Busch DH, Sutter G, Goebel FD, Erfle V
Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.
AIDS Res Hum Retroviruses. 2007;23(6): 782-93

Oboznaya MB, Gilch S, Titova MA, Koroev DO, Volkova TD, Volpina OM, Schätzl HM
Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells.
Cell Mol Neurobiol. 2007;27(3): 271-84

Wedemeyer H, Cornberg M, Protzer U, Berg T, Dollinger MM
[German guidelines on diagnosis and therapy of hepatitis B]
Dtsch Med Wochenschr. 2007;132(34-35): 1775-82

Schlosser E, Otero C, Wuensch C, Kessler B, Edelmann M, Brunisholz R, Drexler I, Legler DF, Groettrup M
A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins.
EMBO Rep. 2007;8(10): 945-51

Schmitz F, Heit A, Guggemoos S, Krug A, Mages J, Schiemann M, Adler H, Drexler I, Haas T, Lang R, Wagner H
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.
Eur J Immunol. 2007;37(2): 315-27

Gilch S, Schmitz F, Aguib Y, Kehler C, Bülow S, Bauer S, Kremmer E, Schätzl HM
CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells.
FEBS J. 2007;274(22): 5834-44

Handisurya A, Gilch S, Winter D, Shafti-Keramat S, Maurer D, Schätzl HM, Kirnbauer R
Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.
FEBS J. 2007;274(7): 1747-58

Tatzelt J, Schätzl HM
Molecular basis of cerebral neurodegeneration in prion diseases.
FEBS J. 2007;274(3): 606-11

Götze KS, Hoffmann D, Schätzl HM, Peschel C, Fend F, Decker T
Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells.
Haematologica. 2007;92(9): 1282-3

Bråve A, Gudmundsdotter L, Gasteiger G, Hallermalm K, Kastenmuller W, Rollman E, Boberg A, Engström G, Reiland S, Cosma A, Drexler I, Hinkula J, Wahren B, Erfle V
Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: Study of immunological memory and long-term toxicology.
Infect Agent Cancer. 2007;2: 14

Maas E, Geissen M, Groschup MH, Rost R, Onodera T, Schätzl H, Vorberg IM
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins.
J Biol Chem. 2007;282(26): 18702-10

Kastenmuller W, Gasteiger G, Gronau JH, Baier R, Ljapoci R, Busch DH, Drexler I
Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.
J Exp Med. 2007;204(9): 2187-98

Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G
Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.
Gastroenterology. 2007;133(4): 1156-65

Kaiser-Schulz G, Heit A, Quintanilla-Martinez L, Hammerschmidt F, Hess S, Jennen L, Rezaei H, Wagner H, Schätzl HM
Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.
J Immunol. 2007;179(5): 2797-807

Uberla K, Rosenwirth B, Ten Haaft P, Heeney J, Sutter G, Erfle V
Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy.
J Med Primatol. 2007;36(1): 2-9

Gilch S, Kehler C, Schätzl HM
Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.
J Mol Biol. 2007;371(2): 362-73

Yun SW, Ertmer A, Flechsig E, Gilch S, Riederer P, Gerlach M, Schätzl HM, Klein MA
The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.
J Neurovirol. 2007;13(4): 328-37

Bohne F, Protzer U
Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B.
J Viral Hepat. 2007;14 Suppl 1: 45-50

Gasteiger G, Kastenmuller W, Ljapoci R, Sutter G, Drexler I
Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines.
J Virol. 2007;81(21): 11925-36

Jost S, Turelli P, Mangeat B, Protzer U, Trono D
Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons.
J Virol. 2007;81(19): 10588-96

Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Duyster J, Elsässer HP, Schätzl HM
The anticancer drug imatinib induces cellular autophagy.
Leukemia. 2007;21(5): 936-42

Simoneau S, Rezaei H, Sales N, Kaiser-Schulz G, Lefebvre-Roque M, Vidal C, Fournier JG, Comte J, Wopfner F, Grosclaude J, Schatzl H, Lasmezas CI
In vitro and in vivo neurotoxicity of prion protein oligomers
PLoS Pathog. 2007;3: 1175-1186

Dagan R, Amir J, Livni G, Greenberg D, Abu-Abed J, Guy L, Ashkenazi S, Foresner G, Froesner G, Tewald F, Schätzl HM, Hoffmann D, Ibanez R, Herzog C
Concomitant administration of a virosome-adjuvanted hepatitis a vaccine with routine childhood vaccines at age twelve to fifteen months: a randomized controlled trial.
Pediatr Infect Dis J. 2007;26(9): 787-93

El-Gogo S, Staib C, Meyr M, Erfle V, Sutter G, Adler H
Recombinant murine gammaherpesvirus 68 (MHV-68) as challenge virus to test efficacy of vaccination against chronic virus infections in the mouse model.
Vaccine. 2007;25(20): 3934-45

Gilch S, Nunziante M, Ertmer A, Schätzl HM
Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.
Vet Microbiol. 2007;123(4): 377-86

Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP
[Prophylaxis, Diagnosis and Therapy of Hepatitis-B-Virus-(HBV-)Infection: upgrade of the guideline, AWMF-Register 021/011]
Z Gastroenterol. 2007;45(6): 525-74

Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP
Prophylaxis, diagnosis and therapy of hepatitis B virus (HBV) infection: the German guidelines for the management of HBV infection.
Z Gastroenterol. 2007;45(12): 1281-328

Gudima S, He Y, Meier A, Chang J, Chen R, Jarnik M, Nicolas E, Bruss V, and Taylor J
Assembly of hepatitis delta virus: particle characterization, including the ability to infect primary human hepatocytes.
J Virol (2007);81:3608-3617.

Gudima S, Meier A, Dunbrack R, Taylor J, and Bruss V
Two potentially important elements of the hepatitis B virus large envelope protein are dispensable for the infectivity of hepatitis delta virus.
J Virol (2007);81:4343-44347.

Bruss V
Hepatitis B virus morphogenesis.
World J Gastroenterol (2007);13:65-73.

2006

Stengel A, Bach C, Vorberg I, Frank O, Gilch S, Lutzny G, Seifarth W, Erfle V, Maas E, Schätzl H, Leib-Mösch C, Greenwood AD
Prion infection influences murine endogenous retrovirus expression in neuronal cells.
Biochem Biophys Res Commun. 2006;343(3): 825-31

Takemura K, Wang P, Vorberg I, Surewicz W, Priola SA, Kanthasamy A, Pottathil R, Chen SG, Sreevatsan S
DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificity.
Exp Biol Med (Maywood). 2006;231(2): 204-14

Untergasser A, Zedler U, Langenkamp A, Hösel M, Quasdorff M, Esser K, Dienes HP, Tappertzhofen B, Kolanus W, Protzer U.
Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection.
Hepatology. 2006;43(3):539-47.

Lehmann MH, Walter S, Ylisastigui L, Striebel F, Ovod V, Geyer M, Gluckman JC, Erfle V
Extracellular HIV-1 Nef increases migration of monocytes.
Exp Cell Res. 2006;312(18): 3659-68

Wolff H, Hadian K, Ziegler M, Weierich C, Kramer-Hammerle S, Kleinschmidt A, Erfle V, Brack-Werner R
Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.
Exp Cell Res. 2006;312(4): 443-56

Lehmann MH, Masanetz S, Kramer S, Erfle V
HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner.
J Cell Sci. 2006;119(Pt 21): 4520-30

Siebler J, Protzer U, Wirtz S, Schuchmann M, Höhler T, Galle PR, Neurath MF.
Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication.
Eur J Gastroenterol Hepatol. 2006;18(2):167-74.

Staib C, Suezer Y, Kisling S, Kalinke U, Sutter G
Short-term, but not post-exposure, protection against lethal orthopoxvirus challenge after immunization with modified vaccinia virus Ankara.
J Gen Virol. 2006;87(Pt 10): 2917-21

von Truchsess I, Harris B, Schätzl HM, Hackett J
The first B/G intersubtype recombinant form of human immunodeficiency virus type 1 (HIV-1) identified in Germany was undetected or underquantitated by some commercial viral load assays.
J Med Virol. 2006;78(3): 311-7

Stengel A, Roos C, Hunsmann G, Seifarth W, Leib-Mösch C, Greenwood AD
Expression profiles of endogenous retroviruses in Old World monkeys.
J Virol. 2006;80(9): 4415-21

Priola SA, Vorberg I
Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies.
Mol Biotechnol. 2006;33(1): 71-88

Gilch S, Kehler C, Schätzl HM
The prion protein requires cholesterol for cell surface localization.
Mol Cell Neurosci. 2006;31(2): 346-53

Kastenmuller W, Drexler I, Ludwig H, Erfle V, Peschel C, Bernhard H, Sutter G
Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity.
Virology. 2006;350(2): 276-88

Schormann W, Kraft A, Ponsel D, and Bruss V
Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase.
J Virol (2006);80:4187-4190.

2005

Harris B, von Truchsess I, Schätzl HM, Devare SG, Hackett J
Genomic characterization of a novel HIV type 1 B/G intersubtype recombinant strain from an injecting drug user in Germany.
AIDS Res Hum Retroviruses. 2005;21(7): 654-60

Moore RA, Vorberg I, Priola SA
Species barriers in prion diseases–brief review.
Arch Virol Suppl. 2005;(19): 187-202

Trieschmann L, Navarrete Santos A, Kaschig K, Torkler S, Maas E, Schätzl H, Böhm G
Ultra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathy.
BMC Biotechnol. 2005;5: 26

Kramer-Hämmerle S, Ceccherini-Silberstein F, Bickel C, Wolff H, Vincendeau M, Werner T, Erfle V, Brack-Werner R
Identification of a novel Rev-interacting cellular protein.
BMC Cell Biol. 2005;6(1): 20

Meyer RG, Britten CM, Siepmann U, Petzold B, Sagban TA, Lehr HA, Weigle B, Schmitz M, Mateo L, Schmidt B, Bernhard H, Jakob T, Hein R, Schuler G, Schuler-Thurner B, Wagner SN, Drexler I, Sutter G, Arndtz N, Chaplin P, Metz J, Enk A, Huber C, Wölfel T
A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
Cancer Immunol Immunother. 2005;54(5): 453-67

Paschen A, Jing W, Drexler I, Klemm M, Song M, Müller-Berghaus J, Nguyen XD, Osen W, Stevanovic S, Sutter G, Schadendorf D
Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.
Int J Cancer. 2005;116(6): 944-8

Jew S, Schatzl HM
Prion: gene, structure, and species barrier.
J Am Osteopath Assoc. 2005;105(1): 23

Nunziante M, Kehler C, Maas E, Kassack MU, Groschup M, Schätzl HM
Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication.
J Cell Sci. 2005;118(Pt 21): 4959-73

Shin EC, Protzer U, Untergasser A, Feinstone SM, Rice CM, Hasselschwert D, Rehermann B.
Liver-directed gamma interferon gene delivery in chronic hepatitis C.
J Virol. 2005;79(21):13412-20.

Hoffmann D, Buchberger B, Nemetz C
In vitro synthesis of enzymatically active HIV-1 protease for rapid phenotypic resistance profiling.
J Clin Virol. 2005;32(4): 294-9

Staib C, Kisling S, Erfle V, Sutter G
Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara.
J Gen Virol. 2005;86(Pt 7): 1997-2006

Heit A, Schmitz F, O’Keeffe M, Staib C, Busch DH, Wagner H, Huster KM
Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines.
J Immunol. 2005;174(7): 4373-80

Isogawa M, Kakimi K, Kamamoto H, Protzer U, Chisari FV.
Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen.
Virology. 2005;333(2):293-300.

Greenwood AD, Horsch M, Stengel A, Vorberg I, Lutzny G, Maas E, Schädler S, Erfle V, Beckers J, Schätzl H, Leib-Mösch C
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells.
J Mol Biol. 2005;349(3): 487-500

Ludwig H, Mages J, Staib C, Lehmann MH, Lang R, Sutter G
Role of viral factor E3L in modified vaccinia virus ankara infection of human HeLa Cells: regulation of the virus life cycle and identification of differentially expressed host genes.
J Virol. 2005;79(4): 2584-96

Quinnan GV, Yu XF, Lewis MG, Zhang PF, Sutter G, Silvera P, Dong M, Choudhary A, Sarkis PT, Bouma P, Zhang Z, Montefiori DC, Vancott TC, Broder CC
Protection of rhesus monkeys against infection with minimally pathogenic simian-human immunodeficiency virus: correlations with neutralizing antibodies and cytotoxic T cells.
J Virol. 2005;79(6): 3358-69

Dumortier J, Schönig K, Oberwinkler H, Löw R, Giese T, Bujard H, Schirmacher P, Protzer U.
Liver-specific expression of interferon gamma following adenoviral gne transfer controls hepatitis B virus replication in mice.
Gene Ther. 2005;12(8):668-77.

Erfle V, Goebel FD, Guzman CA, Le Grand R
Vaccines based on Nef and on Nef/DeltaV2 Env.
Microbes Infect. 2005;7(14): 1400-4

Mühlau M, Bülow S, Stimmer H, Schätzl H, Berthele A
Seronegative Epstein-Barr virus myeloradiculitis in an immunocompetent 72-year-old woman.
Neurology. 2005;65(8): 1329-30

Collin N, Guérin JL, Drexler I, Blanié S, Gelfi J, Boullier S, Foucras G, Sutter G, Messud-Petit F
The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules.
Virology. 2005;343(2): 171-8

Greenwood AD, Stengel A, Erfle V, Seifarth W, Leib-Mösch C
The distribution of pol containing human endogenous retroviruses in non-human primates.
Virology. 2005;334(2): 203-13

Kluge B, Schläger M, Pairan A, and Bruss V
Determination of the minimal distance between the matrix and transmembrane domains of the large hepatitis B virus envelope protein.
J Virol. 2005;79:7918-7921.

2004

Herrmann F, Lehr HA, Drexler I, Sutter G, Hengstler J, Wollscheid U, Seliger B
HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.
Cancer Res. 2004;64(1): 215-20

Cosma A, Bühler S, Nagaraj R, Staib C, Hammarin AL, Wahren B, Goebel FD, Erfle V, Sutter G
Neutralization assay using a modified vaccinia virus Ankara vector expressing the green fluorescent protein is a high-throughput method to monitor the humoral immune response against vaccinia virus.
Clin Diagn Lab Immunol. 2004;11(2): 406-10

Drexler I, Staib C, Sutter G
Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential?
Curr Opin Biotechnol. 2004;15(6): 506-12

Hultström AL, Bratt G, Cosma A, Erfle V, Wahren B, Carbone E
Autologous cytotoxicity of natural killer cells derived from HIV-infected patients.
Immunol Lett. 2004;91(2-3): 155-8

Lotz C, Ferreira EA, Drexler I, Mutallib SA, Huber C, Sutter G, Theobald M
Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man.
Int J Cancer. 2004;108(4): 571-9

Ertmer A, Gilch S, Yun SW, Flechsig E, Klebl B, Stein-Gerlach M, Klein MA, Schätzl HM
The tyrosine kinase inhibitor STI571 induces cellular clearance of PrP^Sc in prion-infected cells.
J Biol Chem. 2004;279(40): 41918-27

Neuendorf E, Weber A, Saalmueller A, Schätzl H, Reifenberg K, Pfaff E, Groschup MH
Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections.
J Biol Chem. 2004;279(51): 53306-16

Zhang Z, Protzer U, Hu Z, Jacob J, Liang TJ.
Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner.
J Virol. 2004;78(9):4566-72.

Vorberg I, Raines A, Priola SA
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro.
J Biol Chem. 2004;279(28): 29218-25

Koopman G, Mortier D, Hofman S, Niphuis H, Fagrouch Z, Norley S, Sutter G, Liljeström P, Heeney JL
Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.
J Gen Virol. 2004;85(Pt 10): 2915-24

Mäkitalo B, Lundholm P, Hinkula J, Nilsson C, Karlén K, Mörner A, Sutter G, Erfle V, Heeney JL, Wahren B, Biberfeld G, Thorstensson R
Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen.
J Gen Virol. 2004;85(Pt 8): 2407-19

Fleischer K, Schmidt B, Kastenmüller W, Busch DH, Drexler I, Sutter G, Heike M, Peschel C, Bernhard H
Melanoma-reactive class I-restricted cytotoxic T cell clones are stimulated by dendritic cells loaded with synthetic peptides, but fail to respond to dendritic cells pulsed with melanoma-derived heat shock proteins in vitro.
J Immunol. 2004;172(1): 162-9

Untergasser A, Protzer U.
Hepatitis B virus-based vectors allow the elimination of viral gene expression and the insertion of foreign promoters.
Hum Gene Ther. 2004;15(2):203-10.

Vorberg I, Raines A, Story B, Priola SA
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents.
J Infect Dis. 2004;189(3): 431-9

Priola SA, Vorberg I
Identification of possible animal origins of prion disease in human beings.
Lancet. 2004;363(9426): 2013-4

Priola SA, Vorberg I
Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies.
Methods Mol Biol. 2004;268: 517-40

Bruss V.
Processing of hepatitis B virus surface proteins.
Methods Mol Med. 2004;95:189-98.

Staib C, Drexler I, Sutter G
Construction and isolation of recombinant MVA.
Methods Mol Biol. 2004;269: 77-100

Polymenidou M, Heppner FL, Pellicioli EC, Urich E, Miele G, Braun N, Wopfner F, Schätzl HM, Becher B, Aguzzi A
Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.
Proc Natl Acad Sci U S A. 2004;101 Suppl: 14670-6

Gilch S, Nunziante M, Ertmer A, Wopfner F, Laszlo L, Schätzl HM
Recognition of luminal prion protein aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP.
Traffic. 2004;5(4): 300-13

Sprinzl M, Dumortier J, Protzer U.
Construction of recombinant adenoviruses that produce infectious hepatitis B virus.
Methods Mol Med. 2004;96:209-18.

Olszewska W, Suezer Y, Sutter G, Openshaw PJ
Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.
Vaccine. 2004;23(2): 215-21

Bruss V
Envelopment of the hepatitis B virus nucleocapsid.
Virus Research (2004);106:199-209.

2003

Whyte SM, Sylvester ID, Martin SR, Gill AC, Wopfner F, Schätzl HM, Dodson GG, Bayley PM
Stability and conformational properties of doppel, a prion-like protein, and its single-disulphide mutant.
Biochem J. 2003;373(Pt 2): 485-94

Hoffmann D, Assfalg-Machleidt I, Nitschko H, von der Helm K, Koszinowski U, Machleidt W
Rapid enzymatic test for phenotypic HIV protease drug resistance.
Biol Chem. 2003;384(7): 1109-17

Schulze-Bergkamen H, Untergasser A, Dax A, Vogel H, Büchler P, Klar E, Lehnert T, Friess H, Büchler MW, Kirschfink M, Stremmel W, Krammer PH, Müller M, Protzer U.
Primary human hepatocytes–a valuable tool for investigation of apoptosis and hepatitis B virus infection.
J Hepatol. 2003;38(6):736-44.

Staib C, Löwel M, Erfle V, Sutter G
Improved host range selection for recombinant modified vaccinia virus Ankara.
Biotechniques. 2003;34(4): 694-6, 698, 700

Bukur J, Rebmann V, Grosse-Wilde H, Luboldt H, Ruebben H, Drexler I, Sutter G, Huber C, Seliger B
Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma.
Cancer Res. 2003;63(14): 4107-11

Nunziante M, Gilch S, Schätzl HM
Prion diseases: from molecular biology to intervention strategies.
ChemBioChem. 2003;4(12): 1268-84

Sutter G, Staib C
Vaccinia vectors as candidate vaccines: the development of modified vaccinia virus Ankara for antigen delivery.
Curr Drug Targets Infect Disord. 2003;3(3): 263-71

Gilch S, Schätzl HM.
Promising developments bringing prion diseases closer to therapy and prophylaxis.
Trends Mol Med. 2003;9(9):367-9.

Demart S, Ceccherini-Silberstein F, Schlicht S, Walcher S, Wolff H, Neumann M, Erfle V, Brack-Werner R
Analysis of nuclear targeting activities of transport signals in the human immunodeficiency virus Rev protein.
Exp Cell Res. 2003;291(2): 484-501

Klöcker U, Oberwinkler H, Kürschner T, Protzer U.
Presence of replicating virus in recombinant hepadnavirus stocks results from recombination and can be eliminated by the use of a packaging cell line.
J Virol. 2003 Mar;77(5):2873-81.

Schätzl HM.
[Present-day knowledge of BSE and Creutzfeldt-Jakob disease]
Gesundheitswesen. 2003;65 Suppl 1: S13-19

Di Nicola M, Carlo-Stella C, Anichini A, Mortarini R, Guidetti A, Tragni G, Gallino F, Del Vecchio M, Ravagnani F, Morelli D, Chaplin P, Arndtz N, Sutter G, Drexler I, Parmiani G, Cascinelli N, Gianni AM
Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trial.
Hum Gene Ther. 2003;14(14): 1347-60

Gilch S, Wopfner F, Renner-Müller I, Kremmer E, Bauer C, Wolf E, Brem G, Groschup MH, Schätzl HM
Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrP^Sc propagation in prion-infected cells.
J Biol Chem. 2003;278(20): 18524-31

Nunziante M, Gilch S, Schätzl HM
Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.
J Biol Chem. 2003;278(6): 3726-34

Meiser A, Boulanger D, Sutter G, Krijnse Locker J
Comparison of virus production in chicken embryo fibroblasts infected with the WR, IHD-J and MVA strains of vaccinia virus: IHD-J is most efficient in trans-Golgi network wrapping and extracellular enveloped virus release.
J Gen Virol. 2003;84(Pt 6): 1383-92

Bronte V, Serafini P, De Santo C, Marigo I, Tosello V, Mazzoni A, Segal DM, Staib C, Lowel M, Sutter G, Colombo MP, Zanovello P
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
J Immunol. 2003;170(1): 270-8

Ritz U, Drexler I, Sutter D, Abele R, Huber C, Seliger B
Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.
J Immunol. 2003;170(2): 941-6

Hornemann S, Harlin O, Staib C, Kisling S, Erfle V, Kaspers B, Häcker G, Sutter G.
Replication of modified vaccinia virus Ankara in primary chicken embryo fibroblasts requires expression of the interferon resistance gene E3L.
J Virol. 2003;77(15): 8394-407

Ohlschläger P, Osen W, Dell K, Faath S, Garcea RL, Jochmus I, Müller M, Pawlita M, Schäfer K, Sehr P, Staib C, Sutter G, Gissmann L
Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice.
J Virol. 2003;77(8): 4635-45

Vogel TU, Reynolds MR, Fuller DH, Vielhuber K, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Marthas ML, Erfle V, Wolinsky SM, Wang C, Allison DB, Rud EW, Wilson N, Montefiori D, Altman JD, Watkins DI
Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.
J Virol. 2003;77(24): 13348-60

Vorberg I, Groschup MH, Pfaff E, Priola SA
Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform.
J Virol. 2003;77(3): 2003-9

Staib C, Sutter G
Live viral vectors: vaccinia virus.
Methods Mol Med. 2003;87: 51-68

Drexler I, Staib C, Kastenmuller W, Stevanovi S, Schmidt B, Lemonnier FA, Rammensee HG, Busch DH, Bernhard H, Erfle V, Sutter G
Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.
Proc Natl Acad Sci U S A. 2003;100(1): 217-22

Cosma A, Nagaraj R, Bühler S, Hinkula J, Busch DH, Sutter G, Goebel FD, Erfle V
Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals.
Vaccine. 2003;22(1): 21-9

Ponsel D und Bruss V
Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation.
J Virol (2003);77:416-422