mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Nat Cell Biol. 2015;17(9): 1205-17

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martinez-Barbera JP, Cutillas P, Reisinger F, Heikenwälder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J

The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

J Pathol. 2015;235(2): 355-67

Ringelhan M, O'Connor T, Protzer U, Heikenwälder M

Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.

Mod Pathol. 2015;28(4): 523-32

Protzer U, Böhm F, Longerich T, Seebach J, Heidary Navid M, Friemel J, Marques-Maggio E, Bawohl M, Heikenwälder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Hepatology. 2015;61(1): 238-48

Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwälder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A

Mouse models for therapeutic vaccination against hepatitis B virus.

Med Microbiol Immunol (Berl). 2015;204(1): 95-102

Dembek C, Protzer U

Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.

J Hepatol. 2015;62(4): 863-70

Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U

Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.

J Virol. 2015;89(5): 2698-709

Thiele F, Tao S, Zhang Y, Muschaweckh A, Zollmann T, Protzer U, Abele R, Drexler I

Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.

Antivir Ther. 2015;20(8): 779-87

Geipel A, Seiz PL, Niekamp H, Neumann-Fraune M, Zhang K, Kaiser R, Protzer U, Gerlich WH, Glebe D, The HOPE consortium

Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.

Parasite Immunol. 2015;37(2): 97-104

Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Solieman A, Protzer U, Busch DH, Layland LE, Prazeres da Costa CU

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

Nat Genet. 2015;47(1): 47-56

Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A

CCL2-CCR2 Signaling in Disease Pathogenesis.

Endocr Metab Immune Disord Drug Targets. 2015;15(2): 105-18

O Connor T, Borsig L, Heikenwälder M

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck.

Oncotarget. 2015;6(5): 3462-70

Jacobi C, Ayx I, Fritsche K, Piontek G, Hoffmann D, Weirich G, Knopf A

Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study.

Infect Agent Cancer. 2015;10(): 31

Schmid SC, Thümer L, Schuster T, Horn T, Kurtz F, Slotta-Huspenina J, Seebach J, Straub M, Maurer T, Autenrieth M, Kübler H, Retz M, Protzer U, Gschwend JE, Hoffmann D

T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.

Gastroenterology. 2015;149(4): 1042-52

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U

Oncogenic potential of hepatitis B virus encoded proteins.

Curr Opin Virol. 2015;14(): 109-15

Ringelhan M, Protzer U

Immunosurveillance of the liver by intravascular effector CD8(+) T cells.

Cell. 2015;161(3): 486-500

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.

J Virol. 2015;89(14): 7433-8

Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Nat Commun. 2015;6(): 8306

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA

Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?

Nat Rev Gastroenterol Hepatol. 2015;12(10): 558-9

Protzer U

Lineage fate of ductular reactions in liver injury and carcinogenesis.

J Clin Invest. 2015;125(6): 2445-57

Jörs S, Jeliazkova P, Ringelhan M, Thalhammer J, Dürl S, Ferrer J, Sander M, Heikenwälder M, Schmid RM, Siveke JT, Geisler F

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

Proc Natl Acad Sci U S A. 2015;112(45): 13982-7

Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J, Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Nat Med. 2015;21(10): 1163-71

Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwälder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.

J Clin Invest. 2015;125(10): 3891-903

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF

Next Generation of Preclinical Liver Cancer Models.

Clin Cancer Res. 2015;21(19): 4254-6

Weber A, O'Connor T, Heikenwälder M

NIK promotes tissue destruction independently of the alternative NF-?B pathway through TNFR1/RIP1-induced apoptosis.

Cell Death Differ. 2015;22(12): 2020-33

Boutaffala L, Bertrand MJ, Remouchamps C, Seleznik G, Reisinger F, Janas M, Bénézech C, Fernandes MT, Marchetti S, Mair F, Ganeff C, Hupalowska A, Ricci JE, Becher B, Piette J, Knolle P, Caamano J, Vandenabeele P, Heikenwalder M, Dejardin E

Intratumor heterogeneity in hepatocellular carcinoma.

Clin Cancer Res. 2015;21(8): 1951-61

Friemel J, Rechsteiner M, Frick L, Böhm F, Struckmann K, Egger M, Moch H, Heikenwälder M, Weber A

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Nat Cell Biol. 2015;17(10): 1370

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martinez-Barbera JP, Cutillas P, Reisinger F, Heikenwälder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Nat Immunol. 2015;16(12): 1235-44

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwälder M, Ben-Neriah Y, Pikarsky E

Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways.

Viruses. 2015;7(9): 4854-72

Wimmer P, Schreiner S

Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.

J Virol. 2015;89(19): 10064-72

Cui X, Luckenbaugh L, Bruss V, Hu J

IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

Hepatology. 2015;62 1(): 1030A-1030A

Li Y, Xia YC, Han MF, Chen G, Thasler WE, Luo XP, Protzer U, Ning Q

Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1/Pre-S2/S vaccine.

Med Microbiol Immunol (Berl). 2015;204(1): 57-68

Shouval D, Roggendorf H, Roggendorf M

RNAi-BASED GENE THERAPY FOR CHRONIC HEPATITIS B: EVALUATION IN A MURINE MODEL

J Hepatol. 2015;62 2(): S526-S526

Michler T, Grosse S, Mockenhaupt S, Heikenwaelder M, Grimm D, Protzer U

Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable.

J Hepatol. 2015;63(1): 13-9

Kefalakes H, Jochum C, Hilgard G, Kahraman A, Bohrer AM, El Hindy N, Heinemann FM, Verheyen J, Gerken G, Roggendorf M, Timm J

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the "magic bullet" to kill cccDNA.

Antiviral Res. 2015;123(): 193-203

Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M

Bispecific antibody constructs mediate specific retargeting towards and elimination of HBV-positive hepatocytes and tumor cells

J Viral Hepat. 2015;22 2(): 8-8

Bohne FM, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U

shRNA Sense Strand Neutralization Reduces Off-Targeting, Ameliorates Toxicity and Enhances Efficacy of RNAi-Based HBV Gene Therapy

Mol Ther. 2015;23 1(): S278-S278

Michler T, Grosse S, Mockenhaupt S, Protzer U, Grimm D

BISPECIFIC ANTIBODY CONSTRUCTS MEDIATE SPECIFIC RETARGETING TOWARDS AND ELIMINATION OF HBV-POSITIVE HEPATOCYTES AND TUMOR CELLS

J Hepatol. 2015;62 2(): S555-S556

Bohne F, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U

Molecular signatures reveal a novel HLA-B(star)15-restricted CD8 T cell epitope on the large hepatitis delta antigen

J Viral Hepat. 2015;22 2(): 109-109

Karimzadeh H, Heinold A, Budeus B, Kosinska A, Buti M, Rizzetto M, Hoffmann D, Protzer U, Roggendorf M

An Aptamer against the Matrix Binding Domain on the Hepatitis B Virus Capsid Impairs Virion Formation.

J Virol. 2015;89(18): 9281-7

Orabi A, Bieringer M, Geerlof A, Bruss V

Towards Autotrophic Tissue Engineering: Photosynthetic Biomaterials for Tissue Regeneration

Tissue Eng Part A. 2015;21 1(): S85-S85

Rosas MNC, Schenck TL, Hopfner U, Centeno C, Machens HG, Somlai-Schweiger I, Heikenwalder M, Bono MR, Schwarz C, Nickelsen J, Allende ML, Egana JT

Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization.

Int J Cancer. 2015;136(10): 2304-15

Seubert B, Cui H, Simonavicius N, Honert K, Schäfer S, Reuning U, Heikenwälder M, Mari B, Krüger A

KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.

J Virol. 2015;90(2): 930-46

Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S