Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection.

Gastroenterology. 2019;156(2): 325-337

Gehring A, Protzer U

Estimation of liver fibrosis by noncommercial serum markers in comparison with transient elastography in patients with chronic hepatitis C virus infection receiving direct-acting antiviral treatment.

J Viral Hepat. 2019;26(2): 224-230

Knop V, Hofmann WP, Buggisch P, Klinker H, Mauss S, Günther R, Hinrichsen H, Hüppe D, Pfeiffer-Vornkahl H, Simon KG, Berg T, Manns MP, Friedrich-Rust M, German Hepatitis C-Registry , Pathil A, Zimmermann T, Heyne R, Goeser T, Ullrich R, Möller H, Geier A, Lutz T, Busch H, Gerken G, Naumann U, Antoni C, Cordes C, John C, Roessle M, Christensen S, Müller T, Hillenbrand H, Herzer K, Jäger H, Felten G, Stoehr A, Scholten S, Kuhn M, Erren P, Cornberg M, Niederau C, Protzer U, Sarrazin C, Schirmacher P, Wedemeyer H, Zeuzem S

Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Sci Transl Med. 2019;11(480):

Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE

Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment.

Eur J Immunol. 2019;49(9): 1321-1333

Matthias J, Zielinski CE

Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology.

Front Immunol. 2019;10():

Palit S, Heuser C, de Almeida GP, Theis FJ, Zielinski CE

Oxeiptosis: a discreet way to respond to radicals.

Curr Opin Immunol. 2019;56(): 37-43

Scaturro P, Pichlmair A

A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection.

Antimicrob Agents Chemother. 2019;64(1):

Ko C, Bester R, Zhou X, Xu Z, Blossey C, Sacherl J, Vondran FWR, Gao L, Protzer U

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis.

Life Sci Alliance. 2019;2(2):

Wing PA, Davenne T, Wettengel J, Lai AG, Zhuang X, Chakraborty A, D'Arienzo V, Kramer C, Ko C, Harris JM, Schreiner S, Higgs M, Roessler S, Parish JL, Protzer U, Balfe P, Rehwinkel J, McKeating JA

Towards curative therapy of chronic viral hepatitis.

Z Gastroenterol. 2019;57(1): 61-73

Bartenschlager R, Urban S, Protzer U

Revisiting Hepatitis B Virus: Challenges of Curative Therapies.

J Virol. 2019;93(20):

Hu J, Protzer U, Siddiqui A

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Sci Rep. 2019;9(1):

Kosinska AD, Moeed A, Kallin N, Festag J, Su J, Steiger K, Michel ML, Protzer U, Knolle PA

Comparative Analysis of the Antiviral Effects Mediated by Type I and III Interferons in Hepatitis B Virus-Infected Hepatocytes.

J Infect Dis. 2019;220(4): 567-577

Bockmann JH, Stadler D, Xia Y, Ko C, Wettengel JM, Schulze Zur Wiesch J, Dandri M, Protzer U

T cell receptor grafting allows virological control of Hepatitis B virus infection.

J Clin Invest. 2019;129(7): 2932-2945

Wisskirchen K, Kah J, Malo A, Asen T, Volz T, Allweiss L, Wettengel JM, Lütgehetmann M, Urban S, Bauer T, Dandri M, Protzer U

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

Cancer Cell. 2019;36(3): 250-267.e9

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwälder M

Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8+ T Cells and Evolve at the Population Level.

Gastroenterology. 2019;156(6): 1820-1833

Karimzadeh H, Kiraithe MM, Oberhardt V, Salimi Alizei E, Bockmann J, Schulze Zur Wiesch J, Budeus B, Hoffmann D, Wedemeyer H, Cornberg M, Krawczyk A, Rashidi-Alavijeh J, Rodríguez-Frías F, Casillas R, Buti M, Smedile A, Alavian SM, Heinold A, Emmerich F, Panning M, Gostick E, Price DA, Timm J, Hofmann M, Raziorrouh B, Thimme R, Protzer U, Roggendorf M, Neumann-Haefelin C

Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse Model.

Mol Ther. 2019;27(5): 947-959

Festag MM, Festag J, Fräßle SP, Asen T, Sacherl J, Schreiber S, Mück-Häusl MA, Busch DH, Wisskirchen K, Protzer U

Chasing Intracellular Zika Virus Using Proteomics.

Viruses. 2019;11(9):

Scaturro P, Kastner AL, Pichlmair A

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.

PLoS Pathog. 2019;15(5):

Płaszczyca A, Scaturro P, Neufeldt CJ, Cortese M, Cerikan B, Ferla S, Brancale A, Pichlmair A, Bartenschlager R

The alternative cap-binding complex is required for antiviral defense in vivo.

PLoS Pathog. 2019;15(12):

Gebhardt A, Bergant V, Schnepf D, Moser M, Meiler A, Togbe D, Mackowiak C, Reinert LS, Paludan SR, Ryffel B, Stukalov A, Staeheli P, Pichlmair A

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

Nat Immunol. 2019;20(4): 493-502

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly.

NAT. MICROBIOL. 2019;4(12): 2416-2429

Neufeldt CJ, Cortese M, Scaturro P, Cerikan B, Wideman JG, Tabata K, Moraes T, Oleksiuk O, Pichlmair A, Bartenschlager R

Generation of recombinant MVA-norovirus: a comparison study of bacterial artificial chromosome- and marker-based systems.

Virol J. 2019;16(1):

Kugler F, Drexler I, Protzer U, Hoffmann D, Moeini H

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.

Nat Commun. 2019;10(1):

Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Eur J Immunol. 2019;49(10): 1457-1973

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A global scientific strategy to cure hepatitis B.

Lancet Gastroenterol Hepatol. 2019;4(7): 545-558

Revill PA, Chisari FV, Block JM, Dandri M, Gehring AJ, Guo H, Hu J, Kramvis A, Lampertico P, Janssen HLA, Levrero M, Li W, Liang TJ, Lim SG, Lu F, Penicaud MC, Tavis JE, Thimme R, Members of the ICE-HBV Working Groups , ICE-HBV Stakeholders Group Chairs , ICE-HBV Senior Advisors , Zoulim F, Arbuthnot P, Boonstra A, Chang KM, Chen PJ, Glebe D, Guidotti LG, Fellay J, Ferrari C, Jansen L, Lau DTY, Lok AS, Maini MK, Mason W, Matthews G, Paraskevis D, Petersen J, Rehermann B, Shin EC, Thompson A, van Bömmel F, Wang FS, Watashi K, Yang HC, Yuan Z, Yuen MF, Block T, Miller V, Protzer U, Bréchot C, Locarnini S, Peters MG, Schinazi RF

Defining the human gut host-phage network through single-cell viral tagging.

NAT. MICROBIOL. 2019;4(12): 2192-2203

Džunková M, Low SJ, Daly JN, Deng L, Rinke C, Hugenholtz P

Using nano-attapulgite clay compounded hydrophilic urethane foams (AT/HUFs) as biofilm support enhances oil-refinery wastewater treatment in a biofilm membrane bioreactor.

Sci Total Environ. 2019;646(): 606-617

Jiang Y, Khan A, Huang H, Tian Y, Yu X, Xu Q, Mou L, Lv J, Zhang P, Liu P, Deng L, Li X

Temperature Response of Planktonic Microbiota in Remote Alpine Lakes.

Front Microbiol. 2019;10():

Jiang Y, Huang H, Ma T, Ru J, Blank S, Kurmayer R, Deng L