1.

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection.

Gehring AJ, Protzer U.

Gastroenterology. 2019 Jan;156(2):325-337. doi: 10.1053/j.gastro.2018.10.032. Epub 2018 Oct 24.

PMID: 30367834 Review.

2.

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U.

J Hepatol. 2018 Dec;69(6):1231-1241. doi: 10.1016/j.jhep.2018.08.012. Epub 2018 Aug 22.

PMID: 30142426

3.

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Dembek C, Protzer U, Roggendorf M.

Curr Opin Virol. 2018 Jun;30:58-67. doi: 10.1016/j.coviro.2018.04.003. Epub 2018 May 8.

PMID: 29751272 Review.

4.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.

Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

PMID: 29491397 Free PMC article.

5.

Correction to 'Viral hepatitis and liver cancer'.

Ringelhan M, McKeating JA, Protzer U.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737):20170339. doi: 10.1098/rstb.2017.0339.

PMID: 29158320 Free PMC article. No abstract available.

6.

Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.

Chen W, Zhang K, Dong P, Fanning G, Tao C, Zhang H, Guo S, Wang Z, Hong Y, Yang X, Lai S, Ding H, Zhao H, Zeng C, Protzer U, Zhang D.

Hepatol Int. 2020 May;14(3):326-337. doi: 10.1007/s12072-020-10016-2. Epub 2020 Feb 25.

PMID: 32100258

7.

The hepatitis B epidemic and the urgent need for cure preparedness.

Lazarus JV, Block T, Bréchot C, Kramvis A, Miller V, Ninburg M, Pénicaud C, Protzer U, Razavi H, Thomas LA, Wallace J, Cowie BC.

Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):517-518. doi: 10.1038/s41575-018-0041-6.

PMID: 30050162 No abstract available.

8.

The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

Velkov S, Ott JJ, Protzer U, Michler T.

Genes (Basel). 2018 Oct 15;9(10):495. doi: 10.3390/genes9100495.

PMID: 30326600 Free PMC article.

9.

Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U.

Oncotarget. 2018 Sep 21;9(74):33947-33960. doi: 10.18632/oncotarget.26103. eCollection 2018 Sep 21.

PMID: 30338037 Free PMC article.

10.

PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.

Xia Y, Schlapschy M, Morath V, Roeder N, Vogt EI, Stadler D, Cheng X, Dittmer U, Sutter K, Heikenwalder M, Skerra A, Protzer U.

Antiviral Res. 2019 Jan;161:134-143. doi: 10.1016/j.antiviral.2018.11.003. Epub 2018 Nov 12.

PMID: 30439382

11.

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors.

Schiwon M, Ehrke-Schulz E, Oswald A, Bergmann T, Michler T, Protzer U, Ehrhardt A.

Mol Ther Nucleic Acids. 2018 Sep 7;12:242-253. doi: 10.1016/j.omtn.2018.05.006. Epub 2018 Jun 7.

PMID: 30195763 Free PMC article.

12.

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D.

Hepatology. 2018 Dec;68(6):2089-2105. doi: 10.1002/hep.30080. Epub 2018 Sep 27.

PMID: 29729204 Free PMC article.

13.

Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

Faure-Dupuy S, Vegna S, Aillot L, Dimier L, Esser K, Broxtermann M, Bonnin M, Bendriss-Vermare N, Rivoire M, Passot G, Lesurtel M, Mabrut JY, Ducerf C, Salvetti A, Protzer U, Zoulim F, Durantel D, Lucifora J.

J Innate Immun. 2018;10(4):339-348. doi: 10.1159/000489966. Epub 2018 Jul 5.

PMID: 29975940 Free PMC article.

14.

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zernecke A, Protzer U.

Antiviral Res. 2018 Mar;151:4-7. doi: 10.1016/j.antiviral.2018.01.001. Epub 2018 Jan 5.

PMID: 29309795

15.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8⁺ T Cells.

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M.

J Virol. 2018 Jun 13;92(13):e01891-17. doi: 10.1128/JVI.01891-17. Print 2018 Jul 1.

PMID: 29669837 Free PMC article.

16.

Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Dultz G, Müller T, Petersen J, Mauss S, Zimmermann T, Muche M, Simon KG, Berg T, Zeuzem S, Hüppe D, Böker K, Wedemeyer H, Welzel TM; Leberstiftungs-GmbH Deutschland.

Drugs Aging. 2018 Sep;35(9):843-857. doi: 10.1007/s40266-018-0572-0.

PMID: 30084012

17.

Estimation of liver fibrosis by noncommercial serum markers in comparison with transient elastography in patients with chronic hepatitis C virus infection receiving direct-acting antiviral treatment.

Knop V, Hofmann WP, Buggisch P, Klinker H, Mauss S, Günther R, Hinrichsen H, Hüppe D, Pfeiffer-Vornkahl H, Simon KG, Berg T, Manns MP, Friedrich-Rust M; German Hepatitis C-Registry.

J Viral Hepat. 2019 Feb;26(2):224-230. doi: 10.1111/jvh.13021. Epub 2018 Nov 8.

PMID: 30315694