2018

Hepatitis B virus promotes ?-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Hepatitis B virus promotes ?-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion.

Oncotarget. 2018;9(74): 33947-33960

von Olshausen G, Quasdorff M, Bester R, Arzberger S, Ko C, van de Klundert M, Zhang K, Odenthal M, Ringelhan M, Niessen CM, Protzer U

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Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Hepatology. 2018;68(6): 2089-2105

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D

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The hepatitis B epidemic and the urgent need for cure preparedness.

The hepatitis B epidemic and the urgent need for cure preparedness.

Nat Rev Gastroenterol Hepatol. 2018;15(9): 517-518

Lazarus JV, Block T, Bréchot C, Kramvis A, Miller V, Ninburg M, Pénicaud C, Protzer U, Razavi H, Thomas LA, Wallace J, Cowie BC

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Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions.

Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions.

J Virol. 2018;92(4):

Freudenberger N, Meyer T, Groitl P, Dobner T, Schreiner S

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Single cell polarity in liquid phase facilitates tumour metastasis.

Single cell polarity in liquid phase facilitates tumour metastasis.

Nat Commun. 2018;9(1): 887

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwälder M

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E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.

E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.

J Virol. 2018;92(13):

Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S

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One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors.

One-Vector System for Multiplexed CRISPR/Cas9 against Hepatitis B Virus cccDNA Utilizing High-Capacity Adenoviral Vectors.

Mol Ther Nucleic Acids. 2018;12(): 242-253

Schiwon M, Ehrke-Schulz E, Oswald A, Bergmann T, Michler T, Protzer U, Ehrhardt A

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Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.

Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.

J Virol. 2018;92(14):

Reichel A, Stilp AC, Scherer M, Reuter N, Lukassen S, Kasmapour B, Schreiner S, Cicin-Sain L, Winterpacht A, Stamminger T

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Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8 T Cells.

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8 T Cells.

J Virol. 2018;92(13):

Karimzadeh H, Kiraithe MM, Kosinska AD, Glaser M, Fiedler M, Oberhardt V, Salimi Alizei E, Hofmann M, Mok JY, Nguyen M, van Esch WJE, Budeus B, Grabowski J, Homs M, Olivero A, Keyvani H, Rodríguez-Frías F, Tabernero D, Buti M, Heinold A, Alavian SM, Bauer T, Schulze Zur Wiesch J, Raziorrouh B, Hoffmann D, Smedile A, Rizzetto M, Wedemeyer H, Timm J, Antes I, Neumann-Haefelin C, Protzer U, Roggendorf M

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Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

J Virol. 2018;92(3):

Inturi R, Mun K, Singethan K, Schreiner S, Punga T

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Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

Characterization of Pattern Recognition Receptor Expression and Functionality in Liver Primary Cells and Derived Cell Lines.

J Innate Immun. 2018;10(4): 339-348

Faure-Dupuy S, Vegna S, Aillot L, Dimier L, Esser K, Broxtermann M, Bonnin M, Bendriss-Vermare N, Rivoire M, Passot G, Lesurtel M, Mabrut JY, Ducerf C, Salvetti A, Protzer U, Zoulim F, Durantel D, Lucifora J

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An orthogonal proteomic survey uncovers novel Zika virus host factors.

An orthogonal proteomic survey uncovers novel Zika virus host factors.

Nature. 2018;561(7722): 253-257

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, P?aszczyca A, Bartenschlager R, Götz M, Pichlmair A

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Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels.

J Hepatol. 2018;69(6): 1231-1241

Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U

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Oxeiptosis-a cell death pathway to mitigate damage caused by radicals.

Oxeiptosis-a cell death pathway to mitigate damage caused by radicals.

Cell Death Differ. 2018;25(7): 1191-1193

Scaturro P, Pichlmair A

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The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data.

Genes (Basel). 2018;9(10):

Velkov S, Ott JJ, Protzer U, Michler T

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Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Nat Immunol. 2018;19(2): 130-140

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A

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Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Drugs Aging. 2018;35(9): 843-857

Dultz G, Müller T, Petersen J, Mauss S, Zimmermann T, Muche M, Simon KG, Berg T, Zeuzem S, Hüppe D, Böker K, Wedemeyer H, Welzel TM, Leberstiftungs-GmbH Deutschland , Günther R, Hinrichsen H, Heyne R, Roth J, Goeser T, Ullrich R, John C, Hofmann WP, Teuber G, Möller H, Baumgarten A, Schwenzer J, Pathil A, Kraus MR, Weber A, Jung MC, Gerken G, Antoni C, Doss MF, Schober A, Hoffstadt M, Lucadou AV, Steffens H, Klinker H, Geier A, Klausen G, Buggisch P, Cornberg M, Sarrazin C, Manns MP, Niederau C, Protzer U, Schirmacher P

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Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

PLoS Pathog. 2018;14(4):

Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G, Pichlmair A

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Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Curr Opin Virol. 2018;30(): 58-67

Dembek C, Protzer U, Roggendorf M

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NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3.

NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3.

J Virol. 2018;92(23):

Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F

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Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle.

Antiviral Res. 2018;151(): 4-7

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zernecke A, Protzer U

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