A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.

Nat Neurosci. 2013;16(11): 1618-26

Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M

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Pathways of metastasizing intestinal cancer cells revealed: how will fighting metastases at the site of cancer cell arrest affect drug development?

Pathways of metastasizing intestinal cancer cells revealed: how will fighting metastases at the site of cancer cell arrest affect drug development?

Future Oncol. 2013;9(1): 1-4

Heikenwalder M, Borsig L

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RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation.

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation.

Cell Rep. 2013;4(4): 776-90

Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T

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A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice.

A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice.

Vaccine. 2013;31(8): 1197-203

Buchmann P, Dembek C, Kuklick L, Jäger C, Tedjokusumo R, von Freyend MJ, Drebber U, Janowicz Z, Melber K, Protzer U

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Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts.

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts.

Virol J. 2013;10(): 151

Vincendeau M, Nagel D, Brenke JK, Brack-Werner R, Hadian K

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Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.

J Virol. 2013;87(8): 4360-71

Benhenda S, Ducroux A, Rivière L, Sobhian B, Ward MD, Dion S, Hantz O, Protzer U, Michel ML, Benkirane M, Semmes OJ, Buendia MA, Neuveut C

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Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.

Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.

Dig Dis. 2013;31(1): 138-51

Ringelhan M, Heikenwalder M, Protzer U

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Role of transmembrane domains of hepatitis B virus small surface proteins in subviral-particle biogenesis.

Role of transmembrane domains of hepatitis B virus small surface proteins in subviral-particle biogenesis.

J Virol. 2013;87(3): 1491-6

Siegler VD, Bruss V

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New norovirus classified as a recombinant GII.g/GII.1 causes an extended foodborne outbreak at a university hospital in Munich.

New norovirus classified as a recombinant GII.g/GII.1 causes an extended foodborne outbreak at a university hospital in Munich.

J Clin Virol. 2013;58(1): 24-30

Hoffmann D, Mauroy A, Seebach J, Simon V, Wantia N, Protzer U

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Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes.

Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes.

Antiviral Res. 2013;97(2): 195-7

Lucifora J, Esser K, Protzer U

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T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.

Gastroenterology. 2013;145(2): 456-65

Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U

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Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.

Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.

Hepatology. 2013;57(6): 2358-68

Sprinzl MF, Reisinger F, Puschnik A, Ringelhan M, Ackermann K, Hartmann D, Schiemann M, Weinmann A, Galle PR, Schuchmann M, Friess H, Otto G, Heikenwalder M, Protzer U

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OMIP-016: Characterization of antigen-responsive macaque and human T-cells.

OMIP-016: Characterization of antigen-responsive macaque and human T-cells.

Cytometry A. 2013;83(2): 182-4

Guenounou S, Bosquet N, Dembek CJ, Le Grand R, Cosma A

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HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

Virology. 2013;440(2): 190-203

Bolduan S, Hubel P, Reif T, Lodermeyer V, Höhne K, Fritz JV, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U

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Nonredundant function of soluble LT?3 produced by innate lymphoid cells in intestinal homeostasis.

Nonredundant function of soluble LT?3 produced by innate lymphoid cells in intestinal homeostasis.

Science. 2013;342(6163): 1243-6

Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA

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Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Immunity. 2013;38(4): 655-68

Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwalder M, Schmidt-Supprian M, Heissmeyer V

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NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium.

NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium.

PLoS ONE. 2013;8(10): e77204

Felmy B, Songhet P, Slack EM, Müller AJ, Kremer M, Van Maele L, Cayet D, Heikenwalder M, Sirard JC, Hardt WD

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Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice.

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice.

Am J Physiol Endocrinol Metab. 2013;304(11): E1140-56

Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL

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Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials.

Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials.

PLoS ONE. 2013;8(10): e76215

Kutscher S, Dembek CJ, Deckert S, Russo C, Körber N, Bogner JR, Geisler F, Umgelter A, Neuenhahn M, Albrecht J, Cosma A, Protzer U, Bauer T

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Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.

Nat Immunol. 2013;14(6): 574-83

Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA

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Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?

Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?

Oncotarget. 2013;4(8): 1117-8

Willimsky G, Protzer U, Knolle P, Heikenwalder M

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.

Nat Neurosci. 2013;16(3): 273-80

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Muller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M

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