A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

A new antigen scanning strategy for monitoring HIV-1 specific T-cell immune responses.

J Immunol Methods. 2012;375(1-2): 46-56

Malnati MS, Heltai S, Cosma A, Reitmeir P, Allgayer S, Glashoff RH, Liebrich W, Vardas E, Imami N, Westrop S, Nozza S, Tambussi G, Buttò S, Fanales-Belasio E, Ensoli B, Ensoli F, Tripiciano A, Fortis C, Lusso P, Poli G, Erfle V, Holmes H

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Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.

BMC Microbiol. 2012;12(): 307

Zhang D, Dong P, Zhang K, Deng L, Bach C, Chen W, Li F, Protzer U, Ding H, Zeng C

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Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Follicular dendritic cells emerge from ubiquitous perivascular precursors.

Cell. 2012;150(1): 194-206

Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A

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Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.

Hepatology. 2012;55(1): 287-97

Hösel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P, Gillen S, Kleeff J, Stabenow D, Odenthal M, Knolle P, Hallek M, Protzer U, Büning H

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TNF-induced target cell killing by CTL activated through cross-presentation.

TNF-induced target cell killing by CTL activated through cross-presentation.

Cell Rep. 2012;2(3): 478-87

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA

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Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.

Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.

J Clin Virol. 2012;55(2): 114-20

Dembek CJ, Kutscher S, Allgayer S, Russo C, Bauer T, Hoffmann D, Goebel FD, Bogner JR, Erfle V, Protzer U, Cosma A

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Design of therapeutic vaccines: hepatitis B as an example.

Design of therapeutic vaccines: hepatitis B as an example.

Microb Biotechnol. 2012;5(2): 270-82

Kutscher S, Bauer T, Dembek C, Sprinzl M, Protzer U

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Sorafenib modulates tumor associated macrophages and enhances anti-cancer NK cell responses

Sorafenib modulates tumor associated macrophages and enhances anti-cancer NK cell responses

Hepatology. 2012;56 1(): 629A-629A

Sprinzl MartinF, Reisinger Florian, Hartmann Daniel, Friess Helmut, Weinmann Arndt, Schuchmann Marcus, Otto Gerd, Galle PeterR, Heikenwaelder Mathias, Protzer Ulrike

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A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.

J Infect Dis. 2012;205(11): 1654-64

Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U

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Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.

J Cancer Res Clin Oncol. 2012;138(5): 843-58

Heindl S, Eggenstein E, Keller S, Kneissl J, Keller G, Mutze K, Rauser S, Gasteiger G, Drexler I, Hapfelmeier A, Höfler H, Luber B

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Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.

Vaccine. 2012;30(42): 6034-9

Farag MM, Tedjokusumo R, Flechtenmacher C, Asen T, Stremmel W, Muller M, Protzer U, Weigand K

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Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Infect Genet Evol. 2012;12(2): 461-6

Hoffmann D, Hutzenthaler M, Seebach J, Panning M, Umgelter A, Menzel H, Protzer U, Metzler D

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Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway.

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway.

Cancer Cell. 2012;22(1): 91-105

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M

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Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Two decades of hepatitis B vaccination in mentally retarded patients: effectiveness, antibody persistence and duration of immune memory.

Vaccine. 2012;30(32): 4757-61

Braeckman T, Van Herck K, Jilg W, Bauer T, Van Damme P

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Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

Gastroenterology. 2012;142(7): 1447-1450.e3

Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U

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Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.

J Virol. 2012;86(18): 10112-22

Schneider M, Ackermann K, Stuart M, Wex C, Protzer U, Schätzl HM, Gilch S

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Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.

J Immunol. 2012;188(12): 5824-8

Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG

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Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.

Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.

PLoS ONE. 2012;7(1): e30054

Diem O, Schäffner M, Seifarth W, Leib-Mösch C

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Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Oncotarget. 2012;3(9): 919-20

Hoos A, Wolf MJ, Bauer J, Borsig L, Heikenwalder M

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Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.

Proc Natl Acad Sci U S A. 2012;109(16): 6259-64

Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T

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HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

HIV-mediated up-regulation of invariant chain (CD74) correlates with generalized immune activation in HIV+ subjects.

Virus Res. 2012;163(1): 380-4

Ghiglione Y, Rodríguez AM, De Candia C, Carobene M, Benaroch P, Schindler M, Salomón H, Turk G

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Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.

Gut. 2012;61(3): 427-38

Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP

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Salmonella transiently reside in luminal neutrophils in the inflamed gut.

Salmonella transiently reside in luminal neutrophils in the inflamed gut.

PLoS ONE. 2012;7(4): e34812

Loetscher Y, Wieser A, Lengefeld J, Kaiser P, Schubert S, Heikenwalder M, Hardt WD, Stecher B

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Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.

Retrovirology. 2012;9(): 82

Koppensteiner H, Brack-Werner R, Schindler M

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Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes.

Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes.

PLoS Pathog. 2012;8(8): e1002867

O'Connor T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A

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Living in the liver: hepatic infections.

Living in the liver: hepatic infections.

Nat Rev Immunol. 2012;12(3): 201-13

Protzer U, Maini MK, Knolle PA

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Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Chromosoma. 2012;121(4): 353-67

Nagel J, Gross B, Meggendorfer M, Preiss C, Grez M, Brack-Werner R, Dietzel S

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Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis.

Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis.

Gastroenterology. 2012;143(5): 1361-74

Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, Macpherson A, Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M

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Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.

Hepatology. 2012;56(3): 873-83

Stross L, Gunther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U

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Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.

J Natl Cancer Inst. 2012;104(23): 1796-807

Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, Weber A, Lim KH, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP

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Lymphotoxin, NF-?B, and cancer: the dark side of cytokines.

Lymphotoxin, NF-?B, and cancer: the dark side of cytokines.

Dig Dis. 2012;30(5): 453-68

Bauer J, Namineni S, Reisinger F, Zöller J, Yuan D, Heikenwalder M

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