Publications

2022

2021

OAS1/RNase L executes RIG-I ligand–dependent tumor cell apoptosis. 

Boehmer, D. F., Formisano, S., de Oliveira Mann, C. C., Mueller, S. A., Kluge, M., Metzger, P., Rohlfs, M., Hörth, C., Kocheise, L., Lichtenthaler, S.F., Hopfner, K.P., Endres, S., Rothenfusser, S., Friedel, C.C., Duewell, P., Schnurr, M. and Koenig, L. M. (2021). 

Science Immunology, 6(61), eabe2550.

 

Nuclear cGAS: guard or prisoner?

de Oliveira Mann, C. C. #, & Hopfner, K. P.# (2021).

The EMBO Journal, 40(16), e108293.

 

Molecular mechanisms of non‐self nucleic acid recognition by the innate immune system.

de Oliveira Mann, C. C.#, & Hornung, V.# (2021).

European Journal of Immunology.

 

2020

Structural basis for sequestration and autoinhibition of cGAS by chromatin

Michalski, S.*, de Oliveira Mann, C. C.*, Stafford, C., Witte, G., Bartho, J., Lammens, K., Hornung. V. and Hopfner, K.-P. (2020)

Nature, 587(7835): 678-682.

 

2019

Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation

de Oliveira Mann, C. C., Orzalli M. H., King D. S., Kagan J. C., Lee A. S. Y.* and Kranzusch P. J.*

Cell Reports, 27.4 (2019): 1165-1175.

 

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

Whiteley A. T., Eaglesham J. B., de Oliveira Mann, C. C., Morehouse B. R., Lowey B., Nieminen E. A., Danilchanka O., King D. S., Lee A. S. Y., Mekalanos J. J.* and Kranzusch P. J.* (2019)

Nature, 567(7747): 194.

 

2018

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance.

Zhou, W.*, Whiteley, A.T.*, de Oliveira Mann, C.C., Morehouse, B.R., Nowak, R.P., Fischer, E.S., Gray, N.S., Mekalanos, J.J. and Kranzusch, P.J., (2018)

Cell 174, 300-311

 

2017

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Drexler, D. J., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., and Hopfner, K.-P. (2017)

Nature 549, 394

 

cGAS conducts micronuclei DNA surveillance

de Oliveira Mann, C. C. and Kranzusch, P. J. (2017)

Trends in Cell Biology 27, 697-698

 

2013 – 2016

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth

Stahl, E., Praetorius, F., de Oliveira Mann, C. C., Hopfner, K.-P., and Dietz, H. (2016)

ACS Nano 10, 9156

 

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

de Oliveira Mann, C. C., Kiefersauer, R., Witte, G., and Hopfner, K.-P. (2016)

Scientific Reports 6, 27498

 

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig, C., Matheisl, S.*, Sparrer, K. M.*, de Oliveira Mann, C. C.*, Moldt, M., Patel, J. R., Goldeck, M., Hartmann, G., García-Sastre, A., Hornung, V., Conzelmann K.-K., Beckmann R., Hopfner K.-P. (2015)

eLife 4, e10859

 

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism

Baer, P.*, Rabe, P.*, Citron, C. A., de Oliveira Mann, C. C., Kaufmann, N., Groll, M., and Dickschat, J. S. (2014)

ChemBioChem 15, 213-216

 

Structural mechanism of cytosolic DNA sensing by cGAS

Civril, F.*, Deimling, T.*, de Oliveira Mann, C. C., Ablasser, A., Moldt, M., Witte, G., Hornung, V., and Hopfner, K.-P. (2013)

Nature 498, 332-337