Misgeld Lab - Publications

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Latest publications

  • [pdf] Wehnekamp F#, Plucińska G#, Thong R, Misgeld T*, Lamb DC*. (2019) Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo. Elife 8. pii: e46059. # equal first-author, *equal senior authors
  • [pdf] Witte M.E., Schumacher A.M., Mahler C.F., Bewersdorf J.P., Lehmitz J., Scheiter A., Sánchez P., Williams P.R., Griesbeck O., Naumann R., Misgeld T*., Kerschensteiner M*. (2019) Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron 101(4):615-624- *equal senior authors.
  • [pdf] Colombo A., Hsia H-E., Wang M., Kuhn P-H., Brill M.S., Canevazzi P., Feederle R., Taveggia C., Misgeld T., Lichtenthaler S.F. (2018) Non-cell-autonomous function of DR6 in Schwann cell proliferation. Accepted EMBOJ-2017-97390R.
  • [pdf] Akassoglou K., Merlini M., Rafalski V.A., Real R., Liang L., Jin Y., Dougherty S.E., De Paola V., Linden D.J., Misgeld T. & Zheng B. (2017) In Vivo Imaging of CNS Injury and Disease. Journal of Neuroscience 37:10808-16.
  • [pdf] Misgeld T. & Schwarz T.L. (2017) Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture. Neuron 96:651-66.
  • [pdf] Mazaheri F., Snaidero N., Kleinberger G., Madore C., Daria A., Werner G., Krasemann S., Capell A., Trümbach D., Wurst W., Brunner B., Bultmann S., Tahirovic S., Kerschensteiner M., Misgeld T., Butovsky O. & Haass C. (2017) TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. EMBO Reports 18:1186-98.
  • [pdf] Heink S., Yogev N., Garbers C., Gasperi C., Herwerth M., Husterer V, Bartsch H.S., Sotlar K., Krebs S., Blum H., Hemmer B., Misgeld T., Hidalgo J., Oukka M., Rose-John S., Schmidt-Supprian M., Waisman A. & Korn T. (2017) Dendritic cells are non-redundant sources of IL-6 for the priming of pathogenic Th17 cells due to a novel mode of IL-6 signalling. Nature Immunology, 18, p74-85.
  • [pdf] Brill M.S., Kleele T., Ruschkies L., Wang M., Marahori N.A., Reuter M., Hausrat T.J., Weigand E., Fisher M., Ahles A., Engelhardt S., Bishop D.L., Kneussel M. & Misgeld T. (2016) Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Neuron, 92, p.845-56.
  • [pdf] Romanelli E., Merkler D., Mezydlo A., Weil M.T., Weber M.S., Nikić I., Potz S., Meinl E., Matznick F.E.H., Kreutzfeldt M., Ghanem A., Conzelmann K.K., Metz I., Brück W., Routh M., Simons M., Bishop D., Misgeld T.* & Kerschensteiner M. Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its model. Nature Communications, 7:13275 (* equal senior authors).
  • [pdf] Engerer P., Fecher C. & Misgeld T. (2016) Super-resolution microscopy writ large. Nature Biotechnology 34, p928-30.

Seminal past publications of the lab

  • [pdf] Breckwoldt MO, Pfister F, Bradley PM, Marinkovic P, Williams PW, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M & Misgeld T (2014) Multi-parametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nature Medicine 20:555-60.
  • [pdf] Sorbara CD, Wagner NE, Ladwig A, Nikic I, Merkler D, Kleele T, Marinković P, Godinho L, Bareyre FM, Bishop D, Misgeld T* & Kerschensteiner M (2014) Pervasive axonal transport deficits in multiple sclerosis models. Neuron 84:1183-90 (* equal senior author)
  • [pdf] Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M & Misgeld T (2014) A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. Nature Communications 5:5683.
  • [pdf] Kleele T, Marinković P, Wiliams PR, Brill M, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl MK, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L & Misgeld T (2014) Imaging of microtubular dynamics in intact mammalian axons. Nature Communications 5:4827.
  • [pdf] Marinković P, Reuter MS, Brill MS, Godinho L, Kerschensteiner M & Misgeld T (2012) Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. PNAS 109:4296-301.
  • [pdf] Bishop D, Nikić I, Brinkoetter M, Knecht S, Potz S, Kerschensteiner M & Misgeld T (2011) Near-infrared branding efficiently correlates light and electron microscopy. Nature Methods 8:568-70.
  • [pdf] Nikić I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeldt M, Bareyre FM, Brück W, Bishop D, Misgeld T* & Kerschensteiner M (2011) A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 17:495-9. (* equal senior author
  • [pdf] Misgeld T, Kerschensteiner M, Bareyre FM, Burgess, RW & Lichtman JW (2007) In vivo imaging axonal transport of mitochondria in mammals. Nature Methods :559-61.
  • [pdf] Misgeld T & Kerschensteiner M In vivo imaging of the diseased nervous system. (2006) Nature Reviews Neuroscience 7:449-63.
  • [pdf] Kerschensteiner M, Schwab M, Lichtman JW & Misgeld T (2005) In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nature Medicine 11:572-577.