Mogler Lab - Vascular biology in liver health and disease
Our research interest is focused on the vascular biology of the liver. The liver is an important organ with essential functions and a specific anatomical architecture. Especially the vascular component represents a highly specialized compartment with a unique type of sinusoidal endothelial cells (LSCE) loosely covered by a layer of pericytes (hepatic stellate cells). Emerging evidence has been given in the last years that angiocrine signaling – molecules produced and secreted by blood vessel components - play a major role in regulating and orchestrating physiological and pathophysiological processes of the liver. Our group aims to identify such new molecules and to understand the biological processes behind. We are also part of the collaborative research consortium 1366 “Vascular control of organ function”.
Our current research projects include:
- Identification of new angiocrine and angiogenic molecules in hepatic neoplasms (carcinomas, vascular tumors, metastasis) and to unravel the biological processes be
- Genetic analysis of vascular tumors of the liver
- Vascular and histopathological classification of rodent models for liver tumorigenesis to improve the reproducibility of histopathological results in biomedical research.
CRC1366:
https://www.sfb1366.de
Collaborations
NGS Core Facility
Comparative Experimental Pathology (CEP)
Translatum
Gewebebank des Klinikums rechts der Isar und der Fakultät für Medizin der TU München
German Cancer Research Center (DKFZ)
European Center for Angioscinec (ECAS)
University hospitals of Heidelberg and Mannheim
University of Ulm
Helmholtz Center Munich