Selected Publications/Patents

Hofmann S, Stubbe M, Mai J, Schreiner S. 2021.Double-edged Role of PML Nuclear Bodies during Human Adenovirus Infection. Virus Res. 2;295:198280. doi: 10.1016/j.virusres.2020.198280.

Stadler D , Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xi Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert M, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Ulrike Protzer. Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20. EMBO Reports. 2021. DOI 10.15252/embr.201949568

Stubbe M, Mai J, Paulus C, Stubbe HC, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay RT, Groitl P, Dobner T, Nevels M., Schreiner S. 2020. HAdV E2A SUMOylation prevents antiviral response promoted by host PML-NB components. mBio. Mar 17;11(2):e00049-20.

Hofmann S,  Mai J, Masser  S, Groitl P, Hermann A, Brack-Werner R, Sternsdorf T and Schreiner S. 2020. ATO (Arsenic Trioxide) effects on PML nuclear bodies reveals antiviral intervention capacity. Advanced Science. Apr; 7(8): 1902130.

Lampl S , Janas M, Donakonda S, Brugger M, Lohr K , Schneider A, Manske K, Sperl L, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost P, Zischka H, Steiger K, Krönke M, Zehn D, Protzer P, Heikenwälder M, Knolle PA, Wohlleber D. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signalling in virus infected hepatocytes. Journal of Hepatology. 2020, 73(6), pp. 1347–1359

Wing P, Davenne, Wettengel J, Lai A, Chakraborty A, D’Arienzo V, Kramer C, Ko C, Harris J, Schreiner S, Higgs M, Parish J, Protzer U, Balfe P, Rehwinkel J  and McKeating JA. A dual role for SAMHD1 in HBV cccDNA synthesis and RT-dependent particle genesis. Life Sciences Alliance. 2020. Mar 27;2(2):e201900355..

Müncheberg S, Hay TR, Ip HW, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S. 2018. E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression. J Virol. Jun 13;92(13).

Reichel A, Stilp AC, Scherer M, Reuter N, Lukassen S, Kasmapour B, Schreiner S, Cicin-Sain L, Winterpacht A, Stamminger T. 2018.The chromatin remodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate-early promoter. J Virol. J Virol. 2018 Jun 29;92(14).

Inturi R., Mun K., Singethan K., Schreiner S, Punga T. 2017. Human Adenovirus Infection Counteracts Antiviral Activity of the celllar MKRN1 E3 Ubiquitin Ligase. J Virol. 2018 Jan 17;92(3).

Schreiner S. and Nassal M. 2017. A role for the host DNA damage response in hepatitis B virus cccDNA formation - and beyond?. Review. Viruses Viruses. 2017 May 22;9(5). pii: E125. doi: 10.3390/v9050125.               

Freudenberger N., Hay R. T., Groitl P., Dobner T., Schreiner S, 2018. HAdV pV core protein is taregeted by the host SUMoylation machinery to pursue essential viral functions. J Virol. Jan30;92(4)

Inturi R., Mun K., Singethan K., Schreiner S, Punga T., 2018. Human Adenovirus Infection Counteracts Antiviral Activity of the celllar MKRN1 E3 Ubiquitin Ligase. J Virol. Jan17;92(3)

Neumann F, Czech-Sioli M, Schmidt C, Dobner T, Grundhoff A, Schreiner S, Fischer N. 2016. Replication of merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies. Journal of General Virology. manuscript accepted.

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S. 2016. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor suppressor p53. Oncogene. 35(1):69-82

Dallaire F, Schreiner S, Blair E, Dobner T, Branton PE and Blanchette P. 2016. The human adenovirus type 5 E4orf6/E1B55K E3 ubiquitin ligase complex can mimic E1A effects on E2F. mSPHERE. manuscript in press.

Dallaire F, Schreiner S, Blair E, Dobner T, Branton PE and Blanchette P. 2016. The human adenovirus type 5 E4orf6/E1B55K E3 ubiquitin ligase complex enhances E1A functional activity. mSPHERE. manuscript in press.

Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T* and Schreiner S*. 2015. KAP1 is a host restriction factor that promotes HAdV E1B-55K SUMO modification. J. Virol. Nov;90(2):930-46.

Berscheminski J, Brun J, Speiseder T, Wimmer P, Ip WH, Terzic M, Dobner T, Schreiner S. Sp100A is a tumor suppressor that activates p53-dependent transcription and countercats E1A/E1B-55K-mediated transformation. Oncogene 2015

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T  and Schreiner S. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor suppressor p53. Oncogene 2015

Schreiner S, Günther T, Tessmer U, Dobner T and Grundhoff A. Influence of ND10 Components on the Epigenetic Determination of Early Kaposi´s Sarcoma-Associated Herpesvirus Latency. PLoS Pathog. 2014; 10(7):e1004274

Berscheminski J, Wimmer P, Brun J, Ip WH, Horlacher T, Groitl P, Jaffray E, Hay RT, Dobner T and Schreiner S. Sp100 isoform-specific regulation of human Adenovirus type 5 (Ad5) gene expression. J Virol. 2014; Jun;88(11):6076-92.

Castillo-Villanueva E, Ballesteros G, Schmid M, Hildago P, Schreiner S, Dobner T, and Gonzalez R. Mre11 cellular protein is modified by conjugation of both SUMO1 and SUMO2/3 during adenovirus infection. ISRN Virology 2014

Schreiner S, Kinkley S, Bürck C, Mund A, Wimmer P, Schubert T, Groitl P and Dobner T. SPOC1-mediated antiviral host cell responses antagonized early in Human Adenovirus type 5 infection. PLoS Pathog. 2013; 9(11):e1003775.

Cheng C, Gilson T, Wimmer P, Schreiner S, Ketner G, Dobner T, Branton P and Blanchette P. The functional role of E1B55K in the E4orf6/E1B55K E3 ligase complexes formed by different human adenovirus serotypes. J Virol. 2013; Jun;87(11):6232-45.

Schreiner S, Bürck C, Glass M, Groitl P, Wimmer P, Kinkley S, Mund A, Everett RD and Dobner T. Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res. 2013; 41(6):3532-50.

Berscheminski J, Groitl P, Dobner T, Wimmer P and Schreiner S. The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumour suppressor PML to enhance viral transcription. J Virol. 2013; 87(2):965-77.

Wimmer P, Blanchette P, Schreiner S, Ching W, Groitl P, Berscheminski J, Branton P, Will H, Dobner T. Cross-talk between Phosphorylation and SUMOylation regulates transforming activities of an adenoviral Oncoprotein. Oncogene 2013; 28;32(13):1626-37.

Müller D, Schreiner S, Schmidt M, Groitl P, Winkler M and Dobner T. Functional cooperation between HAdV5 early region 4 reading frame 6 protein and cellular homeobox protein HOXB7. J Virol. 2012; 86(15):8296-308.

Schreiner S, Martinez R, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Ruzsics Z, Dobner T, Wodrich H. Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. Plos Path. 2012; 8(2). e1002549.

Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T. Adenovirus type 5 early region 1B 55K oncoprotein dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. J Virol. 2011; 85(17):8752-65.

Schreiner S, Wimmer P, Everett RD, Sirma H, Groitl P, Dobner T. 2010. SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. Oncogene; 2010; 29(40):5511-22.

Schreiner S, Wimmer P, Sirma H, Everett R, Blanchette P, Groitl P, Dobner T. Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol. 2010; 84(14):7029-38.

Schreiner S, Kindsmüller K, Leinenkugel F, Groitl P, Kremmer E, Dobner T. A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replication. J Virol 2009; 83(18):9045-56.