Selected Publications/Patents

For the complete list, please follow this link.

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U
Interferon-? and Tumor Necrosis Factor-? Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Gastroenterology. 2016;150(1): 194-205

Meredith LW, Hu K, Cheng X, Howard CR, Baumert TF, Balfe P, van de Graaf KF, Protzer U, McKeating JA
Lentiviral hepatitis B pseudotype entry requires sodium taurocholate co-transporting polypeptide and additional hepatocyte-specific factors.
J Gen Virol. 2016;97(1): 121-7

Geipel A, Seiz PL, Niekamp H, Neumann-Fraune M, Zhang K, Kaiser R, Protzer U, Gerlich WH, Glebe D, The HOPE consortium
Entecavir allows an unexpectedly high residual replication of HBV mutants resistant to lamivudine.
Antivir Ther. 2015;20(8): 779-87

Guidotti LG, Inverso D, Sironi L, Di Lucia P, Fioravanti J, Ganzer L, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M
Immunosurveillance of the liver by intravascular effector CD8(+) T cells.
Cell. 2015;161(3): 486-500

Ringelhan M, Protzer U
Oncogenic potential of hepatitis B virus encoded proteins.
Curr Opin Virol. 2015;14: 109-15

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U
T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.
Gastroenterology. 2015;149(4): 1042-52

Sautto GA, Wisskirchen K, Clementi N, Castelli M, Diotti RA, Graf J, Clementi M, Burioni R, Protzer U, Mancini N
Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein.
Gut. 2015;

Li Y, Xia YC, Han MF, Chen G, Thasler WE, Luo XP, Protzer U, Ning Q
IFN-alpha-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection
Hepatology. 2015;62 1: 1030A-1030A

Schmid SC, Thümer L, Schuster T, Horn T, Kurtz F, Slotta-Huspenina J, Seebach J, Straub M, Maurer T, Autenrieth M, Kübler H, Retz M, Protzer U, Gschwend JE, Hoffmann D
Human papilloma virus is not detectable in samples of urothelial bladder cancer in a central European population: a prospective translational study.
Infect Agent Cancer. 2015;10: 31

Saugel B, Jakobus J, Huber W, Hoffmann D, Holzapfel K, Protzer U, Schmid RM, Umgelter A
Herpes simplex virus in bronchoalveolar lavage fluid of medical intensive care unit patients: Association with lung injury and outcome.
J Crit Care. 2015;

Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U
Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.
J Hepatol. 2015;62(4): 863-70

Michler T, Grosse S, Mockenhaupt S, Heikenwaelder M, Grimm D, Protzer U
RNAi-BASED GENE THERAPY FOR CHRONIC HEPATITIS B: EVALUATION IN A MURINE MODEL
J Hepatol. 2015;62 2: S526-S526

Bohne F, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U
BISPECIFIC ANTIBODY CONSTRUCTS MEDIATE SPECIFIC RETARGETING TOWARDS AND ELIMINATION OF HBV-POSITIVE HEPATOCYTES AND TUMOR CELLS
J Hepatol. 2015;62 2: S555-S556

Ringelhan M, O'Connor T, Protzer U, Heikenwalder M
The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.
J Pathol. 2015;235(2): 355-67

Karimzadeh H, Heinold A, Budeus B, Kosinska A, Buti M, Rizzetto M, Hoffmann D, Protzer U, Roggendorf M
Molecular signatures reveal a novel HLA-B(star)15-restricted CD8 T cell epitope on the large hepatitis delta antigen
J Viral Hepat. 2015;22 2: 109-109

Bohne FM, Hasreiter J, Quitt O, Bockmann JH, Momburg F, Protzer U
Bispecific antibody constructs mediate specific retargeting towards and elimination of HBV-positive hepatocytes and tumor cells
J Viral Hepat. 2015;22 2: 8-8

Hoh A, Heeg M, Ni Y, Schuch A, Binder B, Hennecke N, Blum HE, Nassal M, Protzer U, Hofmann M, Urban S, Thimme R
Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro.
J Virol. 2015;89(14): 7433-8

Thiele F, Tao S, Zhang Y, Muschaweckh A, Zollmann T, Protzer U, Abele R, Drexler I
Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways.
J Virol. 2015;89(5): 2698-709

Hoellein A, Hecker J, Hoffmann D, Göttle F, Protzer U, Peschel C, Götze K
Serious outbreak of human metapneumovirus in patients with hematologic malignancies.
Leuk Lymphoma. 2015;: 1-5

Dembek C, Protzer U
Mouse models for therapeutic vaccination against hepatitis B virus.
Med Microbiol Immunol (Berl). 2015;204(1): 95-102

Protzer U, Böhm F, Longerich T, Seebach J, Heidary Navid M, Friemel J, Marques-Maggio E, Bawohl M, Heikenwalder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A
Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.
Mod Pathol. 2015;28(4): 523-32

Michler T, Grosse S, Mockenhaupt S, Protzer U, Grimm D
shRNA Sense Strand Neutralization Reduces Off-Targeting, Ameliorates Toxicity and Enhances Efficacy of RNAi-Based HBV Gene Therapy
Mol Ther. 2015;23 1: S278-S278

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA
Functional classification of memory CD8(+) T cells by CX3CR1 expression.
Nat Commun. 2015;6: 8306

Protzer U
Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?
Nat Rev Gastroenterol Hepatol. 2015;12(10): 558-9

Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Solieman A, Protzer U, Busch DH, Layland LE, Prazeres da Costa CU
Schistosome infection aggravates HCV-related liver disease and induces changes in the regulatory T-cell phenotype.
Parasite Immunol. 2015;37(2): 97-104

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M
Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes.
Cancer Cell. 2014;26(4): 549-64

Heikenwalder M, Protzer U
LINE(1)s of Evidence in HBV-Driven Liver Cancer.
Cell Host Microbe. 2014;15(3): 249-50

Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H
Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.
Hepatology. 2014;59(6): 2110-20

Golsaz Shirazi F, Mohammadi H, Amiri MM, Singethan K, Xia Y, Bayat AA, Bahadori M, Rabbani H, Jeddi-Tehrani M, Protzer U, Shokri F
Monoclonal antibodies to various epitopes of hepatitis B surface antigen inhibit hepatitis B virus infection.
J Gastroenterol Hepatol. 2014;29(5): 1083-91

Sprinzl MF, Russo C, Kittner J, Allgayer S, Grambihler A, Bartsch B, Weinmann A, Galle PR, Schuchmann M, Protzer U, Bauer T
Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment.
J Viral Hepat. 2014;21(9): 633-41

Lucifora J, Xia Y, Reisinger F, Stadler D, Heikenwälder M, Protzer U
[Specific degradation of nuclear hepatitis B virus covalently closed circular DNA].
Med Sci (Paris). 2014;30(8-9): 724-6

Wuestenberg A, Kah J, Singethan K, Sirma H, Keller AD, Rosal SR, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse AW, Tiegs G, Sass G
Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.
PLoS ONE. 2014;9(5): e96533

Bohne F, Londoño MC, Benítez C, Miquel R, Martínez-Llordella M, Russo C, Ortiz C, Bonaccorsi-Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano JJ, Sánchez-Fueyo A
HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans.
Sci Transl Med. 2014;6(242): 242ra81

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Science. 2014;343(6176): 1221-8

Xia Y, Lucifora J, Reisinger F, Heikenwalder M, Protzer U
Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Science. 2014;344(6189): 1237

Wisskirchen K, Lucifora J, Michler T, Protzer U
New pharmacological strategies to fight enveloped viruses.
Trends Pharmacol Sci. 2014;35(9): 470-478

Lucifora J, Esser K, Protzer U
Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes.
Antiviral Res. 2013;97(2): 195-7

Ringelhan M, Heikenwalder M, Protzer U
Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.
Dig Dis. 2013;31(1): 138-51

Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.
Gastroenterology. 2013;145(2): 456-65

Sprinzl MF, Reisinger F, Puschnik A, Ringelhan M, Ackermann K, Hartmann D, Schiemann M, Weinmann A, Galle PR, Schuchmann M, Friess H, Otto G, Heikenwalder M, Protzer U
Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.
Hepatology. 2013;57(6): 2358-68

Hoffmann D, Mauroy A, Seebach J, Simon V, Wantia N, Protzer U
New norovirus classified as a recombinant GII.g/GII.1 causes an extended foodborne outbreak at a university hospital in Munich.
J Clin Virol. 2013;58(1): 24-30

Benhenda S, Ducroux A, Rivière L, Sobhian B, Ward MD, Dion S, Hantz O, Protzer U, Michel ML, Benkirane M, Semmes OJ, Buendia MA, Neuveut C
Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription.
J Virol. 2013;87(8): 4360-71

Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Nat Immunol. 2013;14(6): 574-83

Willimsky G, Protzer U, Knolle P, Heikenwalder M
Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
Oncotarget. 2013;4(8): 1117-8

Kutscher S, Dembek CJ, Deckert S, Russo C, Körber N, Bogner JR, Geisler F, Umgelter A, Neuenhahn M, Albrecht J, Cosma A, Protzer U, Bauer T
Overnight Resting of PBMC Changes Functional Signatures of Antigen Specific T- Cell Responses: Impact for Immune Monitoring within Clinical Trials.
PLoS ONE. 2013;8(10): e76215

Buchmann P, Dembek C, Kuklick L, Jäger C, Tedjokusumo R, von Freyend MJ, Drebber U, Janowicz Z, Melber K, Protzer U
A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice.
Vaccine. 2013;31(8): 1197-203

Zhang D, Dong P, Zhang K, Deng L, Bach C, Chen W, Li F, Protzer U, Ding H, Zeng C
Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment.
BMC Microbiol. 2012;12: 307

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA
TNF-induced target cell killing by CTL activated through cross-presentation.
Cell Rep. 2012;2(3): 478-87

Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U
Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.
Gastroenterology. 2012;142(7): 1447-1450.e3

Hösel M, Broxtermann M, Janicki H, Esser K, Arzberger S, Hartmann P, Gillen S, Kleeff J, Stabenow D, Odenthal M, Knolle P, Hallek M, Protzer U, Büning H
Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors.
Hepatology. 2012;55(1): 287-97

Stross L, Günther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U
Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice.
Hepatology. 2012;56(3): 873-83

Sprinzl MartinF, Reisinger Florian, Hartmann Daniel, Friess Helmut, Weinmann Arndt, Schuchmann Marcus, Otto Gerd, Galle PeterR, Heikenwaelder Mathias, Protzer Ulrike
Sorafenib modulates tumor associated macrophages and enhances anti-cancer NK cell responses
Hepatology. 2012;56 1: 629A-629A

Hoffmann D, Hutzenthaler M, Seebach J, Panning M, Umgelter A, Menzel H, Protzer U, Metzler D
Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.
Infect Genet Evol. 2012;12(2): 461-6

Dembek CJ, Kutscher S, Allgayer S, Russo C, Bauer T, Hoffmann D, Goebel FD, Bogner JR, Erfle V, Protzer U, Cosma A
Longitudinal changes in HIV-1-specific T-cell quality associated with viral load dynamic.
J Clin Virol. 2012;55(2): 114-20

Krepstakies M, Lucifora J, Nagel CH, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U
A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.
J Infect Dis. 2012;205(11): 1654-64

Schneider M, Ackermann K, Stuart M, Wex C, Protzer U, Schätzl HM, Gilch S
Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain.
J Virol. 2012;86(18): 10112-22

Kutscher S, Bauer T, Dembek C, Sprinzl M, Protzer U
Design of therapeutic vaccines: hepatitis B as an example.
Microb Biotechnol. 2012;5(2): 270-82

Protzer U, Maini MK, Knolle PA
Living in the liver: hepatic infections.
Nat Rev Immunol. 2012;12(3): 201-13

Farag MM, Tedjokusumo R, Flechtenmacher C, Asen T, Stremmel W, Müller M, Protzer U, Weigand K
Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp.
Vaccine. 2012;30(42): 6034-9

Bauer T, Sprinzl M, Protzer U
Immune control of hepatitis B virus.
Dig Dis. 2011;29(4): 423-33

Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, Protzer U
5' Triphosphorylated Small Interfering RNAs Control Replication of Hepatitis B Virus and Induce an Interferon Response in Human Liver Cells and Mice.
Gastroenterology. 2011;141(2): 696-706.e3

Marquardt JU, Quasdorff M, Varnholt H, Curth HM, Mesghenna S, Protzer U, Goeser T, Nierhoff D
Neighbor of punc E11, a novel oncofetal marker for hepatocellular carcinoma.
Int J Cancer. 2011;128(10): 2353-63

Lucifora J, Arzberger S, Durantel D, Belloni L, Strubin M, Levrero M, Zoulim F, Hantz O, Protzer U
Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.
J Hepatol. 2011;55(5): 996-1003

von Freyend MJ, Untergasser A, Arzberger S, Oberwinkler H, Drebber U, Schirmacher P, Protzer U
Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B.
J Viral Hepat. 2011;18(3): 216-26

Vincent IE, Zannetti C, Lucifora J, Norder H, Protzer U, Hainaut P, Zoulim F, Tommasino M, Trépo C, Hasan U, Chemin I
Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.
PLoS ONE. 2011;6(10): e26315

Cornberg M, Protzer U, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Sarrazin C, Dollinger MM, Schirmacher P, Dathe K, Kopp IB, Zeuzem S, Gerlich WH, Manns MP, AWMF , Gerlich W, Löhr H, Protzer U, Rasenack JW, Schaefer S, Schirmacher P, Sprinzl M, Tillmann H, Treichel U, Wittekind C, Cornberg M, Dollinger M, Encke J, Geissler M, Hüppe D, Niederau C, Petersen J, Tannapfel A, van Thiel I, Wasmuth HE, Van Bömmel F, Fiedler M, Geisler F, Göser T, Hinrichsen H, Kautz A, Roeb E, Sarrazin C, Schlaak J, Somasundaram R, von Weizsäcker F, Wedemeyer H, Zachoval R, Bahr M, Bechstein WO, Beckebaum S, Berg T, Jonas S, Kahl A, Kasper HU, Seehofer D, Schlitt HJ, Schmidt H, Sterneck M, Wiegand J, Wursthorn K, Heininger U, Heintges T, Höhler T, Jilg W, Kallinowski B, Radun D, Spengler U, Thimme R, Böhm S, Erhardt A, Klinker H, Mauss S, Oette M, Reiser M, Rockstroh J, Potthoff A, Kaiser R, Hofmann C, Buderus S, Henneke P, Lang T, Melter M, Schmidt-Choudhury A, Wirth S, Zimmer KG, Blum HE, Bock CT, Dienes HP, Fleig WE, Galle PR, Gerken G, Goeser T, Häussinger D, Lammert F, Lohse A, Manns MP, Neuhaus P, Ramadori G, Roeb E, Roggendorf M, Sauerbruch T, Schlitt HJ, Schmidt WE, Schmiegel W, Trautwein C, Wiedenmann B, Wittekind C, Zeuzem S, Bahr MJ, Baumgarten A, Beckebaum S, Berg T, Bock CT, Böcker U, Böker KH, Buderus S, Buggisch P, Capka E, Cornberg M, Deterding K, Dienes HP, Discher T, Dollinger M, Encke J, Erhardt A, Fiedler M, Geisler F, Geissler M, Gerlich WH, Grüngreiff K, Günther R, Heiken H, Hinrichsen H, Hofmann J, Hüppe D, Jilg W, Jonas S, Jung MC, Kautz A, Kirchner G, Kittner J, Lammert F, Manns MP, Mauss S, Müller-Schilling M, Niederau C, Petersen J, Potthoff A, Probst A, Protzer U, Reiser M, Roeb E, Sarrazin C, Schiefke I, Schirmacher P, Schlaak J, Schott E, Spangenberg HC, Spengler U, Tacke F, Trowe E, Urban S, van Bömmel F, van Thiel I, Wagner S, Wedemeyer H, Wiedenmann B, Wirth S, Wursthorn K
[Prophylaxis, diagnosis and therapy of hepatitis B virus infection - the German guideline].
Z Gastroenterol. 2011;49(7): 871-930

Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A
Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.
AIDS Res Ther. 2010;7: 20

Riddell SR, Protzer U
Carving the CAR.
Gene Ther. 2010;17(10): 1191-2

Kutscher S, Allgayer S, Dembek CJ, Bogner JR, Protzer U, Goebel FD, Erfle V, Cosma A
MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays.
Gene Ther. 2010;17(11): 1372-83

Protzer U, Abken H
Can engineered "designer" T cells outsmart chronic hepatitis B?
Hepat Res Treat. 2010;2010: 901216

Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrant K, Protzer U, Knolle PA
Bioluminescence imaging allows measuring CD8 T cell function in the liver.
Hepatology. 2010;51(4): 1430-7

Lucifora J, Vincent IE, Berthillon P, Dupinay T, Michelet M, Protzer U, Zoulim F, Durantel D, Trepo C, Chemin I
Hepatitis B virus replication in primary macaque hepatocytes: crossing the species barrier toward a new small primate model.
Hepatology. 2010;51(6): 1954-60

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.
J Biol Chem. 2010;285(9): 6198-207

Arzberger S, Hosel M, Protzer U
Apoptosis of Hepatitis B Virus-Infected Hepatocytes Prevents Release of Infectious Virus
J Clin Virol. 2010;84(22): 11994-12001

Hoffmann D, Wolfarth B, Hörterer HG, Halle M, Reichhuber C, Nadas K, Tora C, Erfle V, Protzer U, Schätzl HM
Elevated Epstein-Barr virus loads and lower antibody titers in competitive athletes.
J Med Virol. 2010;82(3): 446-51

Hoffmann D, Seebach J, Foley BT, Frösner G, Nadas K, Protzer U, Schätzl HM
Isolated norovirus GII.7 strain within an extended GII.4 outbreak.
J Med Virol. 2010;82(6): 1058-64

Quasdorff M, Protzer U
Control of hepatitis B virus at the level of transcription.
J Viral Hepat. 2010;17(8): 527-36

Arzberger S, Hösel M, Protzer U
Apoptosis of hepatitis B virus-infected hepatocytes prevents release of infectious virus.
J Virol. 2010;84(22): 11994-2001

Sarrazin C, Berg T, Ross RS, Schirmacher P, Wedemeyer H, Neumann U, Schmidt HH, Spengler U, Wirth S, Kessler HH, Peck-Radosavljevic M, Ferenci P, Vogel W, Moradpour D, Heim M, Cornberg M, Protzer U, Manns MP, Fleig WE, Dollinger MM, Zeuzem S
Prophylaxis, Diagnosis and Therapy of Hepatitis C Virus (HCV) Infection: The German Guidelines on the Management of HCV Infection.
Z Gastroenterol. 2010;48(2): 289-351

Protzer CE, Preiss A, Nagel AC
Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye.
Cell Tissue Res. 2009;336(1): 149-58

von Laer D, Baum C, Protzer U
Antiviral gene therapy.
Handb Exp Pharmacol. 2009;(189): 265-97

Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hepatology. 2009;50(6): 1773-82

Stahl S, Sacher T, Bechtold A, Protzer U, Ganss R, Hämmerling GJ, Arnold B, Garbi N
Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma.
Immunol Lett. 2009;123(1): 31-7

Op den Brouw ML, Binda RS, van Roosmalen MH, Protzer U, Janssen HL, van der Molen RG, Woltman AM
Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus.
Immunology. 2009;126(2): 280-9

Jenke AC, Wilhelm AD, Orth V, Lipps HJ, Protzer U, Wirth S
Long-term suppression of hepatitis B virus replication by short hairpin RNA expression using the scaffold/matrix attachment region-based replicating vector system pEPI-1.
Antimicrob Agents Chemother. 2008;52(7): 2355-9

Quasdorff M, Hösel M, Odenthal M, Zedler U, Bohne F, Gripon P, Dienes HP, Drebber U, Stippel D, Goeser T, Protzer U
A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation.
Cell Microbiol. 2008;10(7): 1478-90

Bohne F, Chmielewski M, Ebert G, Wiegmann K, Kürschner T, Schulze A, Urban S, Krönke M, Abken H, Protzer U
T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.
Gastroenterology. 2008;134(1): 239-47

Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP, German Society for Digestive and Metabolic Diseases , German Society for Pathology , Society for Virology , Society for Pediatric Gastroenterology and Nutrition , Competence Network for Viral Hepatitis
The German guideline for the management of hepatitis B virus infection: short version.
J Viral Hepat. 2008;15 Suppl 1: 1-21

Wedemeyer H, Cornberg M, Protzer U, Berg T, Dollinger MM
[German guidelines on diagnosis and therapy of hepatitis B]
Dtsch Med Wochenschr. 2007;132(34-35): 1775-82

Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G
Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection.
Gastroenterology. 2007;133(4): 1156-65

Nierhoff D, Marquardt J, Quasdorff MJ, Holz G, Arnold B, Protzer U, Goeser T
Neighbor of Punc E11 (Nope): A novel marker for murine hepatocellular carcinoma
Hepatology. 2007;46: 525A-526A

Quasdorff MJ, Nierhoff D, Holz G, Goeser T, Protzer U
Active replication of hepatitis B virus (HBV) starts after birth
Hepatology. 2007;46: 636A-636A

Quasdorff MJ, Hoesel M, Odenthal M, Zedler U, Bohne F, Drebber U, Nguyen TH, Gripon P, Stippel D, Goeser T, Protzer U
Expression levels of HNF4a link efficient HBV replication to hepatocyte differentiation state
Hepatology. 2007;46: 645A-645A

Protzer U, Seyfried S, Quasdorff M, Sass G, Bohne F, Hosell M, Schirmacher P, Tiegs G
Antiviral activity and hepatoprotection by heme oxygenase-1 in models of human hepatitis B infection
J Hepatol. 2007;46 1: S161-S161

Bohne F, Chmielewski M, Ebert G, Schulze A, Urban S, Kurschner T, Abken H, Protzer U
T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes
J Hepatol. 2007;46 1: S43-S43

Bohne F, Protzer U
Adoptive T-cell therapy as a therapeutic option for chronic hepatitis B.
J Viral Hepat. 2007;14 Suppl 1: 45-50

Jost S, Turelli P, Mangeat B, Protzer U, Trono D
Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons.
J Virol. 2007;81(19): 10588-96

Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP
Prophylaxis, diagnosis and therapy of hepatitis B virus (HBV) infection: the German guidelines for the management of HBV infection.
Z Gastroenterol. 2007;45(12): 1281-328

Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP
[Prophylaxis, Diagnosis and Therapy of Hepatitis-B-Virus-(HBV-)Infection: upgrade of the guideline, AWMF-Register 021/011]
Z Gastroenterol. 2007;45(6): 525-74

Selected Publications before 2007

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Untergasser A, Zedler U, Langenkamp A, Hösel M, Quasdorff M, Esser K, Tapperzhofen B, Kolanus W and Protzer U.
Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection.
Hepatology 2006, 43: 539-547.

Siebler J, Protzer U, Wirtz S, Schuchmann M, Hohler T, Galle PR, Neurath MF.
Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication.
Eur J Gastroenterol Hepatol. 2006,18:167-74.

Shin E-C, Protzer U, Untergasser A, Feinstone SM, Rice CM, Hasselschwert D, Rehermann B.
Liver-Directed Interferon-? Gene Delivery in Chronic Hepatitis C.
Journal of Virology 2005, 79:13412-13420.

Isogawa M, Kakimi K, Kamamoto H, Moriyasu F, Protzer U and Chisari FV.
Differential Dynamics of the Peripheral and Intrahepatic Cytotoxic T Lymphocyte Response to a Secreted Viral Antigen Produced in the Liver.
Virology 2005, 333: 293-300.

Dumortier J, Schönig K, Giese T, Bujard H, Protzer U.
The Tet-system allows tight control and liver-specific gene expression in vivo following adenoviral gene transfer into mice.
Gene Therapy 2005, 12:668-677.

Zhang Z, Protzer U, Hu Z, Jacob J, Liang TJ.
Inhibition of cellular proteasome activities enhances hepadnaviral replication in a HBx dependent manner.
Journal of Virology 2004, 78: 4566-4572.

Untergasser A & Protzer U.
Hepatitis B virus vectors allow elimination of viral gene expression and insertion of foreign promoters.
Human Gene Therapy 2004, 15: 203-210.

Sprinzl M, Dumortier J, Protzer U.
Construction of recombinant adenoviruses that produce infectious hepattis B virus.
Methods in Molecular Medicine 2004, 96:203-218.

Schulze-Bergkamen H, Untergasser A, Dax A, Vogel H, Büchler P, Klar E, Lehnert T, Friess H, Büchler M, Kirschfink M, Stremmel W, Krammer P, Müller M, Protzer U.
Primary human hepatocytes – a valuable tool for investigation of apoptosis and hepatitis B virus infection
Journal of Hepatology 2003, 38: 736-744.

Klöcker U, Kürschner T, Oberwinkler H, Protzer U.
Presence of replicating virus in recombinant hepadnavirus stocks results from homologous recombination and can be eliminated be the use of a packaging cell line.
Journal of Virology 2003, 77 (5): 2873-2881.

Li Y, Hacker HJ, Protzer U, Kopp-Schneider A, Bannasch P.
Woodchuck Hepatitis B Virus Replication and Antigen Expression Gradually Decreases in Preneoplastic Hepatocellular Lineages
Journal of Hepatology 2002, 37 (4): 478.

Sprinzl M, Oberwinkler H, Schaller H, Protzer U.
Hepatitis B virus genome transfer with adenoviral vectors into cultured cells and mice: crossing the species barrier.
Journal of Virology 2001, 75: 5108-5118.

Radecke K, Protzer U, Trippler M, Gerken G.
Variation of the Hepatitis B Virus Core Gene during High-dose Interferon Alpha Therapy.
Journal of Medical Virology 2000, 62: 479-486.

Klöcker U, Schultz U, Schaller H, Protzer U.
Liver macrophages release mediators after endotoxin stimulation that inhibit an early step in hepadnavirus replication.
Journal of Virology 2000, 74 (12): 5525-5533.

Hegenbarth S, Gerolami R, Protzer U, Tran PL, Brechot C, Gerken G, Knolle PA.
Liver sinusoidal endothelial cells are not permissive for adenovirus type 5
Human Gene Therapy 2000, 11 (3): 481-486.

Protzer U, Nassal M, Chiang PE, Kirschfink M, Schaller H.
Interferon gene transfer by a novel hepatitis B virus vector efficiently suppresses wildtype-virus infection.
PNAS 1999, 96: 10818-10823.

Herr W, Protzer U, Lohse A, Meyer zum Büschenfelde KH, Wölfel T.
Characterization of cytotoxic T-cell response in HIV infected patients and seronegative high-risk contact persons.
Journal of Infectious Diseases 1998,178: 260-165.

Protzer U, Naumann U, Bartenschlager R, Berg T, Hopf U, Meyer zum Büschenfelde KH, Neuhaus P, Gerken G.
Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation.
Hepatology 1998, 27(1): 254-263.

Naumann U, Protzer U, Berg T, Leder K, Lobeck H, Fukumoto T, Bechstein WO, Gerken G, Hopf U, Neuhaus P.
A pretransplant infection with precore mutants of Hepatitis B Virus does not influence the outcome of orthotopic liver transplantation in patients on high-dose anti-HBs immuno-prophylaxis.
Hepatology 1997, 26 (2): 478-484.

Protzer U, Ochsendorf FR, Leopolder-Ochsendorf A, Holtermüller KH.
Exacerbation of Lichen Planus during Interferon-Alpha-2a Therapy of Chronic Active Hepatitis C.
Gastroenterology 1993; 104 (3): 903-905.