Selected Publications


Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G and Pichlmair A; Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity. Plos Pathogens, accepted

Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A: Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol. 2018 Feb;19(2):130-140. doi: 10.1038/s41590-017-0013-y.


Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, Pichlmair A, Lundmark R, Överby AK.; Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles. J Virol. 2017 Oct 18. pii: JVI.01751-17

Goonawardane N, Gebhardt A, Bartlett C, Pichlmair A, Harris M. Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions. J Virol. 2017 Aug 10;91(17).

Brady G, Haas DA, Farrell PJ, Pichlmair A, Bowie AG.Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation. J Virol. 2017 Jul 12;91(15). pii: e00545-17.

Gebhardt A, Laudenbarch B, Pichlmair A; Discrimination of self and non-self ribonucleic acids.: J Interferon Cytokine Res. 2017 May;37(5):184-197.

Abbas YM, Laudenbach BT, Martínez-Montero S, Cencic R, Habjan M, Pichlmair A., Damha MJ, Pelletier J, Nagar B.; Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc Natl Acad Sci. 2017 Mar 14;114(11):E2106-E2115.

Willemsen J, Wicht O, Wolanski JC, Baur N, Bastian S, Haas DA, Matula P, Knapp B, Meyniel-Schicklin L, Wang C, Bartenschlager R, Lohmann V, Rohr K, Erfle H, Kaderali L, Marcotrigiano J, Pichlmair A, Binder M.; Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening. Mol Cell. 2017 Feb 2;65(3):403-415.e8. doi: 10.1016/j.molcel.2016.12.021.


Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI.; A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN. Cell Reports, 2016 Apr 14. doi: 10.1016/j.celrep.2016.03.077.


Stukalov A, Pichlmair A.; Gambling with Flu: "All in" to Maximize Reward. Cell Host Microbe, 2015 Dec 9;18(6):643-5.

Gebhardt A., Habjan M., Benda C., Meiler A., Haas D.A., Hein M.Y., Mann A., Mann M., Habermann B. and Pichlmair A.; mRNA export through an additional cap-binding complex consisting of NCBP1 and -3. Nature Communications, 2015, Sep 18;6:8192. doi: 10.1038/ncomms9192.

Heinz L.X., Baumann C.L., Köberlin M.S., Snijder B., Gawish R., Shui G., Sharif O., Aspalter I.M., Müller A.C., Kandasamy R.K., Breitwieser F.P., Pichlmair A., Bruckner M., Rebsamen M., Blüml S., Karonitsch T., Fauster A., Colinge J., Bennett K.L., Knapp S., Wenk M.R., Superti-Furga G.; The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Reports, 2015, Jun 30;11(12):1919-28.

Brady G., Haas D.A., Farrell P.J., Pichlmair A., Bowie A.G.; Poxvirus protein MC132 from Molluscum Contagiosum Virus inhibits NFκB activation by targeting p65 for degradation. J Virol, 2015, Aug;89(16):8406-15.

Habjan M., Pichlmair A.; Cytoplasmic sensing of viral RNA; Curr op. Virology, 2015, Apr;11:31-37.


Eberle C.A., Zayas M., Stukalov A., Pichlmair A., Alvisi G., Müller A.C., Bennett K.L., Bartenschlager R., Superti-Furga G.; The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production. Virology, 2014, Aug;462-463:34-41.

Upadhyay A.S., Vonderstein K., Pichlmair A., Stehling O., Bennett K.L., Dobler G., Guo J.T., Superti-Furga G., Lill R., Overby A.K., Weber F.; Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity. Cell Microbiol, 2014, Jun;16(6):834-48.

Kainulainen M., Habjan M., Hubel P., Busch L., Lau S., Colinge J., Superti-Furga G., Pichlmair A., Weber F.; Virulence factor NSs of Rift Valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol, 2014, Mar;88(6):3464-73.

Liehl P., Zuzarte-Luís V., Chan J., Zillinger T., Baptista F., Carapau D., Konert M., Hanson K.K., Carret C., Lassnig C., Müller M., Kalinke U., Saeed M., Chora A.F., Golenbock D.T., Strobl B., Prudêncio M., Coelho L.P., Kappe S.H., Superti-Furga G., Pichlmair A., Vigário A.M., Rice C.M., Fitzgerald K.A., Barchet W., Mota M.M.; Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med, 2014, Jan;20(1):47-53.


Habjan M, Hubel P, Lacerda L, Benda C, Holze C, Eberl CH, Mann A, Kindler E, Gil-Cruz C, Ziebuhr J, Thiel V, Pichlmair A. Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA. PLoS Pathog, 2013, Oct;9(10):e1003663.

Abbas, YM., Pichlmair, A., Górna, MW., Superti-Furga, G., Nagar, B.; Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins.; Nature, 2013, Feb 7;494(7435).60-4.


Pichlmair, A., Kandasamy, K., Alvisi, G., Mulhern, O., Sacco, R., Habjan, M., Binder, M., Stefanovic, A., Eberle, C.A., Goncalves, A., Bürckstümmer, T., Müller, A., Fauster, A., Holze, A., Lindsten, K., Goodbourn, S., Kochs, G., Weber, F., Bartenschlager, R., Bowie, A.G., Bennett, K.L., Colinge, J. and Superti-Furga. G; Viral immune modulators perturb the human molecular network by common and unique strategies.; Nature, 2012, Jul 26;487(7408):486-90.


Pichlmair, A., Lassnig. C., Eberle C.A., Górna M.W., Baumann C.L., Burkard T.R., Bürckstümmer T., Stefanovic A., Krieger S., Bennett K.L., Rülicke T., Weber F., Colinge J., Müller M., Superti-Furga G.; IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA.; Nat Immunol, 2011, Jun 5;12(7):624-30.


Baumann, C.L., Aspalter, I.M., Sharif, O., Pichlmair. A., Blüml, S., Grebien, F., Bruckner, M., Pasierbek, P., Aumayr, K., Planyavsky, M., Bennett, K.L., Colinge, J., Knapp, S., Superti-Furga, G.; CD14 is a coreceptor of Toll-like receptors 7 and 9.; J Exp Med, 2010, Nov 22;207(12):2689-701.

Pichlmair, A., Habjan, M., Unger, H., Weber, F.; Virus-Like Particles Expressing the Nucleocapsid Gene as an Efficient Vaccine Against Rift Valley Fever Virus.; Vector-Borne and Zoonotic Diseases, 2010, Oct;10(7):701-3

Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, NC., Scheuner, D., Kato, H., Takeuchi, O., Akira, S., Kaufman, RJ., Reis e Sousa, C.; Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.; Cell Host Microbe, 2010, May 20;7(5):354-61.

Rehwinkel, J., Tan, CP., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., Reis e Sousa, C.; RIG-I detects viral genomic RNA during negative-strand RNA virus infection.; Cell, 2010, Feb 5;140(3):397-408.


Pichlmair, A., Schulz, O., Tan, CP., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., Reis e Sousa, C.; Activation of MDA5 requires higher-order RNA structures generated during virus infection.; J Virol, 2009, Oct;83(20):10761-9.

Pichlmair, A.*, Habjan, M.*, Elliott, RM., Overby, AK., Glatter, T., Gstaiger, M., Superti-Furga, G., Unger, H., Weber, F.; NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase; J Virol, 2009, May; 83(9):4365-75. *contributed equally


Habjan, M., Andersson, I., Klingström, J., Schümann, M., Martin, A., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Mühlberger, E., Mirazimi, A., Weber, F.; Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction; PLoS One, 2008, Apr 30; 3(4):e2032.


Pichlmair, A. and Reis e Sousa, C.; Innate recognition of viruses; Immunity, 2007, Sep 21;27(3): 370-383

Pichlmair, A., Diebold, S.S., Gschmeissner, S., Takeuchi, Y., Ikeda, Y., Collins, M.K. and Reis e Sousa, C.; Tubulovesicular Structures within Vesicular Stomatitis Virus G Protein-Pseudotyped Lentiviral Vector Preparations Carry DNA and Stimulate Antiviral Responses via Toll-Like Receptor 9; J Virol, 2007, Jan; 81(2): 539-47


Pichlmair, A., Schulz, O., Tan, C.P., Näslund, T.I., Liljeström, P., Weber, F. and Reis e Sousa, C.; RIG-I-mediated antiviral responses to single stranded RNA bearing 5’ phosphates; Science, 2006, Nov; 314: 997-1001


Spiegel, M., Pichlmair, A., Martínez-Sobrido, L., Cros, J., García-Sastre, A., Haller, O. and Weber, F.: Inhibition of interferon-beta induction by SARS coronavirus suggests a two-step model for activation of interferon regulatory factor 3; J Virol, 2005, Feb; 79(4): 2079-86


Pichlmair, A., Buse, J., Jennings, S., Haller, O., Kochs, G. and Staeheli, P.: Thogoto Virus lacking interferon – antagonistic factor ML is strongly attenuated in Mx1-positive but not Mx1-negative mice; J Virol, 2004, Oct; 78(20): 11422-4