We are developing methods and devices to measure health-related parameters non-invasively. Just imagine getting your blood work done without any needles, but by using light and by sensing the resulting ultrasound waves on your skin surface. Chemical contrast is achieved label-free by the wavelength-specific absorption of relevant molecules. The optoacoustic (=photoacoustic) effect transforms the absorbed light energy into sound waves that can be measured on the skin with an ultrasound transducer. Machine learning helps to interpret the measured data and to differentiate between noise and signal. One of our projects is to non-invasively measure glucose in blood (#GLUMON).