Selected Publications

2016 2015 2014 2013 2012 2011


Meng Z, Zhang XY, Pei RJ, Zhang E, Kemper T, Vollmer J, Davis HL, Glebe D, Gerlich W, Roggendorf M, 4Lu M. Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral responses and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection. Antiviral Res. 2016; 125: 14-24


Sadeghi A, Yahyapour Y, Poortahmasebi V, Shahmoradi S, Roggendorf M, Karimzadeh H, Alavian SM, Jazayeri SM. Clearance of HBV DNA in immunized children born to HBsAg positive mothers, years after being diagnosed with occult HBV infection. J Viral Hepat. 2015; Noc 24. Doi: 10.1111/jvh. 12490 [Epub ahead of print]

Zhang E, Kosinska A, Lu M, Yan H. and Roggendorf M. Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the “magic bullet” to kill cccDNA. Antiviral Research 2015; 123: 193-2013

Lindemann M, Koldehoff M, Fiedler M, Schumann A, Ottinger HD, Heinemann FM, Roggendorf M, Horn PA, and Beelen DW. Control of hepatitis B virus infection in hematopoietic stem cell recipients after receiving grafts from vaccinated donors. Letter to the Editor Bone Marrow Transplant. 2015; 1-4

Tawar RG, Colpitts CC, Timm J, Fehm T, Roggendorf M, Meisel H, Meyer N, Habersetzer F, Cosset FL, Berg T, Zeisel MB, Baumert TF. Acute hepatitis C virus infection induces anti-host cell receptor antibodies with virus-neutralizing properties. Hepatology 2015; 62: 726-736

Ross RS, Wolters B, Hoffmann B, Geue L, Viazov S, Grüner N, Roggendorf M, and Müller T. Instructive even after a decade: complete results of initial virological diagnostics and re-evaluation of molecular data in the German rabies virus „outbreak“ caused by transplantations. Int J Med Microbiol. 2015; 305: 636-643

Grüner N, Viazov S, Korn K, Knöll A, Trippler M, Schlaak JF, Gerken G, Roggendorf M, and Roß RS. Performance characteristics of the VERSANT hepatitis C virus RNA 1.0 (kPCR) assay. Int J Med Microbiol. 2015; 305: 627-635

Schumann A, Fiedler M, Beckebaum S, Cicinnati V, Herzer K, Lenz V, Witzke O, Paul A, Roggendorf M, Horn P, Lindemann M. Donor- and recipient-derived immunity in ABO incompatible living-related liver transplantation. Hum Immunol. 2015; 76: 631-635

Wu W, Dietze KK, Gibbert K, Lang KS, Trilling M, Yan H, Wu J, Yang D, Lu M, Roggendorf M, Dittmer U, Liu J. TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection," Sci Rep. 2015 May 31; 5: 10501

Roggendorf M, Kosinska AD, Liu J, and Lu M. The woodchuck, a non-primate model for immune pathogenesis and therapeutic immunomodulation in chronic hepatitis B virus infection. CS Book review. In: Seeger C and Locarnini S (Eds.) “Hepatitis B and Delta Viruses. Additional Perspectives on Hepatitis B and Delta Viruses” Cold Spring Harbor Laboratory Press 2015, pp.

Kefalakes H, Jochum C, Hilgard G, Kahraman A, Bohrer AM, Hindy NE, Heinemann FM, Verheyen J, Gerken G, Roggendorf M, Timm J. Decades after recovery from hepatitis B and HBsAg clearance the CD8+ T cell response against HBV core is nearly undetectable Article. J Hepatol. 2015; 63(1): 13-19

Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of Herpes Simplex Virus induced Stromal Keratitis by a glycoprotein B-specific monoclonal antibody. PLoS ONE 2015; 10(1): 1-24

Zhang E, Kosinska A, Ma Z, Dietze KK, Xu Y, Meng Z, Zhang XY, Wang JH, Wang BJ, Dittmer U, Roggendorf M, Yang DL, Lu M. Woodchuck hepatitis virus core antigen-based DNA and protein vaccines induce qualitatively different immune responses that affect T cell recall responses and antiviral effects. Virology 2015; 475: 56-65

Pishraft Sabet L, Kosinska A, Rafati S, Bolhassani A, Taheri T, Memarnejadian A, Alavian SM, Roggendorf M, and Samimi-Rad K. Enhancement of HCV polytope DNA vaccine efficacy by fusion to an N-terminal fragment of heat shock protein gp96. Arch Virol. 2015; 160: 141-152

Shouval D, Roggendorf H, Roggendorf M. Enhanced Immune Response to Hepatitis B vaccination Through Immunization with a PreS1/PreS2/S Vaccine. In: Roggendorf M (Hrsg.) “Therapeutic vaccination in chronic hepatitis B – approaches, problems, and new perspectives”. Med Microbiol Immunol. 2015; 204: 57-68

Kosinska AD, Liu J, Lu M. Roggendorf M. Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck. In: Roggendorf M (Hrsg.) “Therapeutic vaccination in chronic hepatitis B – approaches, problems, and new perspectives”. Med Microbiol Immunol. 2015; 204: 103-114

Roggendorf M. Therapeutic vaccination in chronic hepatitis B – approaches, problems, and new perspectives. Special Issue of the Med Microbiol Immunol: 2015; 204: Springer Verlag


Daram M, Montazeri G, Karimzadeh H, Malekzadeh R, Mahmoodi M, Goodarzi Z, Keyvani H, Mirmomen S, Alavian SM, Roggendorf M, Jazayeri SM. Surface protein mutations in chronic hepatitis B patients who received hepatitis B vaccine therapy. Iran J Basic Med Sci. 2014; 17:638-645

Krawczyk A, Ludwig C, Jochum C, Fiedler M, Heinemann FM, Shouval D, Roggendorf M, Roggendorf H, Lindemann M. Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination  against hepatitis B by using a third generation PreS/S vaccine. J Vaccine 2014; 32: 5077-5082

Locarnini SA and Roggendorf M. Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV)). Chapter 8 in “Viral Hepatitis” 4th Edition. (Eds.: Thomas HC, Lok ASF, Locarnini SA, and Zuckerman AJ). Published 2014 by John Wiley & Sons, Ltd.  

Lange M, Fiedler M, Bankwitz D, Osburn W, Viazov S, Brovko O, Zekri AR, Khudyakov Y, Nassal M, Pumpens P, Pietschmann T, Timm J, Roggendorf M, Walker A. Hepatitis C Virus Hypervariable Region 1 Variants Presented on Hepatitis B Virus Capsid-Like Particles Induce Cross-Neutralizing Antibodies. Plos One 2014; Jul 11; 9(7): e102235

Ludwig C, Krawczyk A, Heinemann FM, Horn PA, Fiedler M, Roggendorf M, Roggendorf H, Lindemann M. Influence of HLA Class II antigens on the response to a third generation hepatitis B vaccine in non- and low-responders. Tissue Antigens 2014; 84: 11

Lipskoch M, Wiese M, Timm J, Roggendorf M, Viazov S. Genetic heterogeneity of hepatitis C virus cell entry receptors seems to have no influence on selection of virus variants. Virol J. 2014; 11: 50

Liu J, Kosinska A, Lu M, Roggendorf M. New therapeutic vaccination strategies for the treatment of chronic hepatitis B. Virol Sin. 2014; 29: 10-16

Meng Z, Ma ZY, Zhang E, Kosinska AD, Liu J, Zhang XY, Zhou TL, Wu J, Dahmen U, Dirsch O, Yang DL, Roggendorf M, Lu M. Novel woodchuck hepatitis virus (WHV) transgene mouse models show sex-dependent WHV replicative activity and development of spontaneous immune response to WHV proteins. J Virol. 2014, 88: 1573-1581

Liu J, Zhang E, Ma Z, Wu W, Kosinska A, Zhang X, Möller I, Seiz P, Glebe D, Wang B, Yang DL, Lu M, Roggendorf M. Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog. 2014; 10(1):e1003856


Liu J, Jiang M, Ma ZY, Dietze KK, Zelinskyy G, Yang DL, Dittmer U, Schlaak JF, Roggendorf M, Lu M. Toll-Like Receptor 1/2 Ligands Stimulated Mouse Liver Endothelial Cells Secrete Interleukin 12 and Trigger CD8+ T Cell Immunity In Vitro. J Immunol. 2013; 191: 6178-6190

Krawczyk A, Roggendorf H, Ludwig C, Herzer K, Gerken G, Horn PA, Roggendorf M, Lindemann M. Therapeutic vaccination of a liver transplant recipient suffering from fulminant hepatitis B during pregnancy. Liver Transpl. 2013; 19:1411-1412

Roggendorf M, Kosinska A, Liu J, Lu M. Perspectives for better treatment of chronic hepatitis B. In: Viral Hepatitis and Liver diseases – Two decades ahead (Wen Y, ‘Yang S, Wang H, Hui Z, Zheng S (Eds)), Chinese Academy of Engineering, Higher Education Press 2013, pp. 126-143

Vratskikh O, Stiasny K, Zlatkovic J, Tsouchnikas G, Jarmer J, Karrer U, Roggendorf M, Roggendorf H, Allwinn R, Heinz FX. Dissection of antibody specificities induced by yellow fever vaccination. PLoS Pathog. 2013; 9: e1003458

Meng Z; Zhang X; Wu J; Pei R; Xu Y; Yang D; Roggendorf M, Lu M. RNAi induces innate immunity through multiple cellular signaling pathways. PLoS One 2013; 8: e64708

Krawczyk A, Arndt MAE, Grosse-Hovest L, Weichert W, Giebel B, Dittmer U, Hengel H, Jäger D, Schneweis KE, Eis-Hübinger AM, Roggendorf M, Krauss J. Overcoming drug resistant Herpes simplex virus (HSV) infection in vitro and in immunocompromised mice by a novel humanized antibody. PNAS USA 2013; 110:6760-6765

Kosinska AD, Zhang E, Johrden L, Seiz PL, Liu J, Zhang XY, Kemper T, Fiedler M, Glebe D, Wildner O, Dittmer U, Lu M, and Roggendorf M. Combination of DNA prime – adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model . PloS Pathogenes 2013; 9: 1-17

Fiedler M, Kosinska AD, Schumann A, Brovko O, Walker A, Lu M, Johrden L, Mayer A, Wildner O, and Roggendorf M. Prime/Boost immunization with DNA and adenoviral vectors protects from hepatitis D virus (HDV) infection after simultaneous infection with HDV and woodchuck hepatitis virus. J Virol. 2013; 87:7708 - 7716

Ross RS, Stambouli, O, Grüner N, Marcus U, Cai W, Zhang WD, Zimmermann R, and Roggendorf M. Detection of infections with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus by analysis of dried blood spots – performance characteristics of the ARCHITECT system and two commercial assays for nucleic acid amplification. Virology Journal 2013; 10: 72

Wolters B, Müller T, Ross RS, Kundt R, Roggendorf M, Roggendorf H. Hepatitis A/B-Kombinationsimpfung: Evaluation eines Impfprogramms in Werkstätten für Menschen mit Behinderung. Gesundheitswesen 2013; 75: 1-7

Roß RS und Roggendorf M. Rhabdoviren. In Fischer SF, AlDahouk S, Brandt C et al. (Eds.) MiQ 33 Zoonosen. Elsevier Urban & Fischer Verlag 2013, pp. 93-101

Trebicka J, Anadol E, Elfimova N, Strack I, Roggendorf M, Viazov S, Wedemeyer I, Drebber U, Rockstroh J, Sauerbruch T, Dienes HP, and Odenthal M. Hepatic and serum levels of miR-122 after chronic HCV induced fibrosis. J Hepatol. 2013; 58: 234-239


Jiang M, Liu J, Zhang E, Meng Z, Wang B, Roggendorf M, Yang D, Lu M, Xu Y. Molecular characterization of woodchuck interleukin-10 receptor and enhanced function of specific T cells from chronically infected woodchucks following its blockade. Comp Immunol Microbiol Infect Dis. 2012; 35: 563-573

Pei R, Zhang X, Xu S. Meng Z, Roggendorf M, Lu M, and Chen X. Regulation of hepatitis C virus replication and gene expression by MAPK-ERK pathway. Virol Sin. 2012; 27: 278-285

Roggendorf M. Perspectives for a vaccine against hepatitis delta virus. Semin Liver dis. 2012; 32: 256-261

Fan H, Zhu Z, Wang Y, Zhang X, Lu Y, Tao Y, Fan W, Wang Z, Wang H, Roggendorf M, Lu M, Wang B, Yang D. Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV). Cytokine. 2012; 60:179-185

Zhang X, Ma Z, Liu H, Liu J, Meng Z, Broering R, Yang D, Schlaak JF, Roggendorf M, Lu M. Role of Toll-like receptor 2 in the immune response against hepadnaviral infection. J Hepatol. 2012; 57: 522-528

Sallam TA, Raja'a YA, Bahaj S, Al-Shami AM, Lu M, Roggendorf M, Tong CY. Hepatitis B virus carrier rate, prevalence and susceptibility and impact of immunization program among households in the city of Taiz, Yemen. Vaccine. 2012; 30: 5564-5568

Roggendorf H, Santibanez S, Mankertz A, van Treeck U, Roggendorf M. Two consecutive measles outbreaks with genotypes D8 and D4 in two mainly unvaccinated communities in Germany. Med Microbiol Immunol. 2012; 201: 349-355

Kosinska AD, Johrden L, Zhang E, Fiedler M, Mayer A, Wildner O, Lu M, Roggendorf M. DNA Prime – Adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model. J Virol. 2012; 86: 9297-9310

Timm J and Roggendorf M. Plasticity of the hepatitis C virus genome. In: Hacker J, Dobrindt U, Kurth R (Eds.) “Genome Plasticity and Infectious Diseases”, 2012 ASM Press, Washington DC, pp. 178-190


Zhang E, Zhang X, Liu J, Wang B, Tian Y, Kosinska AD, MA z, Xu Y, Dittmer U, Roggendorf M, Yang D, Lu M. The expression of PD-1 ligands and their involvement in regulation of T cellfunctions in acute and chronic woodchuck hepatitis virus infection. PLoS One 2011; 6:e26196

Stein A, Keller M, Ross S, Roggendorf M, Heitmann F, Hoehn T, Göpel W, Felderhoff-Müser U, Härtel C. Pandemic A/H1N1 (2009) influenca infections in very-low-birth-weight infants – a case series from the German Neonatla Network. Klin Paediatr. 2011; 223: 267-270

Wang BJ, Bao JJ,Wang JZ, Wang Y, Jiang M, Xing MY, Zhang WG, Qi JY, Roggendorf M, Lu MJ, Yang DL. Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma. World J Gastroenterol. 2011; 17: 3322-3329

Zelinskyy G, Myers L, Dietze KK, Gibbert K, Roggendorf M, Liu J, Lu M, Kraft AR, Teichgräber V, Hasenkrug KH, Dittmer U. Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute fried retrovirus infection but are highly cytotoxic and control virus replication. J Immunol. 2011; 187: 3730-3737

Cornberg M, Protzer U, Petersen J. Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Sarrazin C, Dollinger MM, Schirmacher P, Dathe K, Kopp IB, Zeuzem S, Gerlich WH, Manns MP, AWMF. Prophylaxis, diagnosis and therapy of hepatitis B virus infection – the German guideline. Z Gastroenterol. 2011; 49: 871-930

Nattermann J, Timm J, Nischalke HD, Olbrich A, Michalk M, Tilmann HL, Berg T, Wedemeyer H, Tenckhof H, Wiese M, Kullig U, Göbel U, Capka E, Schiefke I, Güthoff W, Grüngreiff K, König I, Roggendorf M, Sauerbruch T, Spengler U, and German anti-D study group. The predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5&[Delta]32 mutation. J Hepatol. 2011; 55:1201-1206

Ruhl M, Knuschke T, Schewior K, Glavinic L, Neumann-Haefelin C, Chang DI, Klein M, Heinemann FM, Tenckhoff H, Wiese M, Horn PA, Viazov S, Spengler U, Roggendorf M, Scherbaum N, Nattermann J, Hoffmann D, Timm J; East German HCV Study Group. CD8(+)T-cell response promotes evolution of hepatitis C virus non-structural proteins. Gastroenterology 2011; 140: 2064-2073

Gieseler RK, Marquitan G, Schlattjan M, Sowa JP, Bechmann LP, Timm J, Roggendorf M, Gerken G, Friedmann SL, Canbay A. Hepatocyte apoptotic bodies encasing non-structural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitic C. J Viral Hepat. 2011; 18: 760-767

Roggendorf H, Sprave T, S Hertel, Morscheck F, Roggendorf M. Die Influenza-Impfrate bei Mitarbeitern eines Universitätsklinikums. Status Quo und geeignete Verbesserungsstrategien. Dtsch med Wschr. 2011; 136: 1299-1304

Zhang X, Zhang E, Ma Z, Pei R, Jiang M, Schlaak JF, Roggendorf M, Lu M. Modulation of hepatitis B virus replication and hepatocyte differentiation by microRNA-1. Hepatology 2011; 53: 1476-1485

Krawczyk A, Krauss J, Eis-Hübinger AM, Däumer MP, Schwarzenbacher R, Dittmer U, Schneweis KE, Jäger D, Roggendorf M, and Arndt MA. Impact of valency of a glycoprotein B specific monoclonal antibody on neutralization of herpes simplex virus. J Virol. 2011; 85: 1793-1803

Wang BJ, Tian YJ, Meng ZJ, Jiang M, Wei BQ, Tao YQ, Fan W, Li AY, Bao JJ, Li XY, Zhang ZM, Wang ZD, Wang H, Roggendorf M, Lu MJ, Yang DL. Establishing a new animal model for hepadnaviral infection : susceptibility of chinese Marmota-species to woodchuck hepatitis virus infection. J Gen Virol 2011; 92: 681-691

Schulte I, Hitziger T, Giugliano S, Timm J, Gold H, Heinemann F, Khudyakov Y, Strasser M, König C, Castermans E, Mok JY, van Esch WJE, Bertoletti A, Schumacher TN, Roggendorf M. Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection. J Hepatol. 2011; 54: 201-208

Zhang Z, Li L, Zhao XP, Glebe D, Bremer CM, Zhang ZM, Tian YJ, Wang BJ, Yang Y, Gerlich W, Roggendorf M, Li X, Lu M, Yang DL. Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance. J Viral Hepat. 2011; 18: 424-433

Vetter JM, Frisch L, Drosten C, Ross RS, Roggendorf M, Wolters B, Müller T, Dick HB, Pfeiffer N. Survival after transplantation of corneas from a rabies-infected donor. Cornea 2011; 30: 241-244