2021
Schmitt N., Jann J-C, Altrock E., Flach J., Danner J., Uhlig S., Streuer A., Knaflic A., Riabov V., Xu Q., Mehralivand A., Palme I., Nowak V., Obländer J., Weimer N., Haselmann V., Jawhar A., Darwich A., Weis C-A., Marx A., Steiner L., Jawhar M., Metzgeroth G., Boch T., Nolte F., Hofmann W-K., Nowak D. Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes. Leukemia 2021 Jun. [Read here...]
Fröbel J., Landspersky T., Percin G., Schreck C., Rahmig S., Ori A., Nowak D., Essers M., Waskow C.* and Oostendorp R.A.J.*. *Contributed equally. The Hematopoietic Bone Marrow Niche Ecosystem. Front. Cell Dev. Biol., 22 July 2021 [Read here...]
2020
Kreutmair S., Klingeberg C. , Poggio T. , Andrieux G., Keller A., Miething C., Follo M., Pfeifer D., Shoumariyeh K., Lengerke C., Gonzalez-Menendez I., Fend F., Zeiser R., Turner S. D, Quintanilla-Martinez L., Boerries M., Duyster J., Illert A. L. Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model. Leukemia 2020 Mar 17. [Read here…]
Jann J-C., Streuer A., Hecht A., Nolte F., Nowak V., Danner J., Obländer J., Palme I., Lengfelder E., Platzbecker U., Hofmann W-K., Flach J., Nowak D. RNA-sequencing of acute promyelocytic leukemia
primary blasts reveals novel molecular biomarkers of early death events. Leukemia and Lymphoma 2020 Jul. [Read here...]
Flach J, Jann J-C., Knaflic A., Riabov V., Streuer A., Altrock E., Xu Q., Schmitt N., Obländer J., Nowak V., Danner J., Mehralivand A., Hofmann F., Palme I., Jawhar A., Wuchter P., Metzgeroth G., Nolte F., Hofmann W-K., and Nowak D. Replication stress signaling is a therapeutic target in Myelodysplastic Syndromes with splicing factor mutations. Haematologica 2020. [Read here...]
Sommerkamp P., Altamura S., Renders S., Narr A., Ladel L., Zeisberger, P., Eiben Pl., Fawaz M., Rieger MA., Cabezas-Wallscheid N., Trumpp, A. Differential Alternative Polyadenylation Landscapes Mediate Hematopoietic Stem Cell Activation and Regulate Glutamine Metabolism. Cell stem cell May 2020 [Read here…]
Kreutmair S., Erlacher M., Andrieux G., Istvanffy R., Mueller-Rudorf A., Zwick M., Rückert T., Pantic M., Poggio T., Shoumariyeh K., Mueller T.A., Kawaguchi H., Follo M., Klingeberg K., Wlodarski M., Baumann I., Pfeifer D., Kulinski M., Rudelius M., Lemeer S., Kuster B., Dierks C., Peschel C., Cabezas-Wallscheid N., Duque-Afonso J., Zeiser R., Cleary M.L., Schindler D., Schmitt-Graeff A., Boerries M., Niemeyer C.M., Oostendorp R.A.J., Duyster J., Illert A.L. Loss of the Fanconi anemia–associated protein NIPA causes bone marrow failure. The Journal of Clinical Investigation 2020 Apr. [Read here…]
Romero Marquez S., Hettler F., Hausinger R., Schreck C., Landspersky T., Henkel L., Angerpointner C., Demir I.E., Schiemann M., Bassermann F., Götze K.S., Istvánffy R., Oostendorp A.J. Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells. Haematologica Early view Nov 19, 2020 [Read here…]
Riabov V., Mossner M., Stohr A., Jann J-C., Streuer A., Schmitt N., Knaflic A., Nowak V., Weimer N., Obländer J., Palme I., Schumann C., Baldus C.D., Schulze T.J., Wuchter P., Röhl H., Jawhar A., Weiss C., Boch T., Metzgeroth G., Neumann M., Hofmann W-C., Nolte F. and Nowak D. High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes. British Journal of Haematology 2021,192,879–891 [mehr...]
Weickert M-T, Hecker J., Buck M., Schreck C., Rivière J., Schiemann M., Schallmoser K., Bassermann F., Strunk D., Oostendorp R.A.J. and Götze K. Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression. Sci Rep 2021 Mar 15 [mehr...]
2019
Mende N., Jolly A., Percin G.I., Günther M., Rostovskaya M., Krishnan S.M., Oostendorp R.A.J., Dahl A., Anastassiadis K., Höfer T., Waskow C. Prospective isolation of nonhematopoietic cells of the nicheand their differential molecular interactions with HSCs. Blood. 2019;134(15):1214-1226. [Read here...]
Yu C. , Gorantla S., Müller-Rudorf A., Müller T., Kreutmair S., Albers C., Jakob L., Lippert L., Zhenyu Yue Z., Engelhardt M., Follo M., Zeiser R., Huber T., Duyster J., Illert A. L. Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia. Haematologica. 2020 May; Epub 2019 Aug 8. [Read here...]
Rudorf A., Müller T., Klingeberg C., Kreutmair S., Poggio T., Prasad Gorantla S., Rückert T., Schmitt-Graeff A., Gengenbacher A., Paschka P. Baldus C., Robert Zeiser R., Vassiliou G. S., Bradley A., Duyster J., Illert A. L. NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia. Blood. 2019 Jul 25;134(4):383-388. [Read here…]
Müller T., Pennisi S., Zwick A., Decker S., Klein C., Rister B., Rudorf A., Kissel S., Follo M., Wäsch R., Illert A. L., Pfeifer D., Oostendorp R., Waskow C., Dierks C., Duyster J. PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion. Leukemia. 2019 May;33(5):1296-1301. [Read here…]
Jacome-Galarza C. J., Percin G. I., Muller J., Mass E., Lazarov T., Eitler J., Rauner M., Yadav V. K., Crozet L., Bohm M., Loyher P.-L., Karsenty G., Waskow C., and Geissmann F. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature. 2019 Apr. [Read here...]
2018
Arndt K., Kranz A., Fohgrub J., Jolly A., Bledau A.S., Di Virgilio M., Lesche M., Dahl A., Höfer T., Stewart A.F. and Waskow C. (2018). SETD1A protects HSCs from activation-induced functional decline in vivo. Blood 2018. [Read here...]
Percin G.I., Eitler J., Kranz A., Fu J., Pollard J.W., Naumann R., Waskow C. CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. 2018 Dec 11;9(1):5279. [Read here...]
Frobel J., Rahmig S., Franzen J., Waskow C., Wagner W. Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice. Clinical Epigenetics 67 (2018) . [Read here...]
2017
Hirche C, Frenz T, Haas S, Döring M, Borst K. Tegtmeyer P, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. (2017). Systemic Virus Infections differentially modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, Cell Rep. 2017 Jun 13;19(11). [Read here...]
Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann W-K, Ho AD, Huber W, Trumpp A#, Essers MAG#, Steinmetz LM#. (2017). Human haematopoietic stem cell lineage commitment is a continuous process. Nat. Cell Biol. 19: 271-281 # shared corresponding autho. [Read here...]
Garz A-K, Wolf S, Grath S, Gaidzik V, Habringer S, Vick B, Rudelius M, Ziegenhain C, Herold S, Weickert M-T, Smets M, Peschel C, Oostendorp R, Bultmann S, Jeremias I, Thiede C, Döhner K, Keller U, Götze K. Azacitidinecombined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiation cells in FLT3-ITD AML with concurrent epigenetic mutations. Oncotarget 2017, October.[Read here...]
Schreck C*, Istvánffy R*, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian C, Mende N, Taubenberger A, Prendergast A, Wagner A, Pagel C, Grziwok S, Götze K, Guck J, Dean D, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp R. Niche WNT5A regulates the actin cytoskeleton duringregeneration of hematopoietic stem cells. JEM 2017, Jan. [Read here...]
2016
Müller TA, Grundler R, Istvanffy R, Rudelius M, Hennighausen L, Illert AL, Duyster J. Lineage specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype. Leukemia. 2016 Apr 5. doi: 10.1038/leu.2016.72. [Read here...]
Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, and Trumpp A. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause. Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.[Read here...]
Klein C, Zwick A, Kissel S, Forster C U, Pfeifer D, Follo M, Illert A L, Decker S, Benkler T, Pahl H, Oostendorp R, Aumann K, Duyster J, and Dierks C. Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. J Exp Med 2016 213:273-290. Published February 1, 2016 [Read here...]
Jilg S, Reidel V, Müller-Thomas C, König J, Schauwecker J, Höckendorf U, Huberle C, Gorka O, Schmidt B, Burgkart R, Ruland J, Kolb HJ, Peschel C, Oostendorp RAJ, Götze KS, Jost PJ. Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients. Leukemia. 2016 Jan;30(1):112-23. doi: 10.1038/leu.2015.179. Epub 2015 Jul 8. [Read here...]
Uckelmann H, Blaszkiewicz S,* Nicolae C,* Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A and Essers M. Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. JEM. 2016 Sept 19 [Read here...]
Ruf F, Schreck C, Wagner A, Grziwok S, Pagel C, Romero S, Kieslinger M, Shimono A, Peschel C, Götze KS, Istvanffy R, Oostendorp R. Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool. Stem Cells. 2016 Jun 30 [Read here...]
Diesch J, Zwick A, Garz A-K, Palau A, Buschbeck M, Götze K. A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers. Clin Epigenetics. 8,71 [Read here...]
Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, Bassermann F. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.Nat Med. 2016 Jul;22(7):735-43. doi: 10.1038/nm.4128. Epub 2016 Jun 13. [Read here...]
Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornha ̈M, Gassmann M, Platz A, Ordemann R, Tonn T, Waskow C. Regeneration in Hematopoiesis and Animal Models in Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice. StemCell Reports 2016 [Read here...]
2015
Waskow C. Maintaining What Is Already There: Strategies to Rectify HSC Transplantation Dilemmas. Cell Stem Cell. 2015 Sep 3;17(3):258-9. doi: 10.1016/j.stem.2015.08.012. [Read here...]
Istvánffy R, Vilne B, Schreck C, Ruf F, Pagel C, Grziwok S, Henkel L, Prazeres da Costa O, Berndt J, Stümpflen V, Götze KS, Schiemann M, Peschel C, Mewes HW, Oostendorp RAJ. Stroma-Derived Connective Tissue Growth Factor Maintains Cell Cycle Progression and Repopulation Activity of Hematopoietic Stem Cells In Vitro. Stem Cell Reports. 2015 Nov 10;5(5):702-15. doi: 10.1016/j.stemcr.2015.09.018. Epub 2015 Oct 29. [Read here...]
Franke K, Vilne B, Prazeres da Costa O, Rudelius M, Peschel C, Oostendorp RAJ, Keller U. In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment. Oncotarget. 2015 Sep 8;6(26):21827-39. [Read here...]
Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RAJ, Massberg S, Fässler R. Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. J Exp Med. 2015 Aug 24;212(9):1415-32. doi: 10.1084/jem.20150269. Epub 2015 Aug 17. [Read here...]
Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA. Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell. 2015;17: 422-34. doi: 10.1016/j.stem.2015.07.007. Epub 2015 Aug 20 [Read here...]
Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015 Jul 27;212(8):1171-83. doi: 10.1084/jem.20150308. Epub 2015 Jul 6. [Read here...]
V Tomiatti, R Istvánffy, E Pietschmann, S Kratzat, A Hoellein, L Quintanilla-Fend, N von Bubnoff, C Peschel, RAJ Oostendorp, U Keller. Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors. Oncogene. 2015; 34(33):4347-57. doi: 10.1038/onc.2014.364. Epub 2014 Nov 24 [Read here...]
Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell. 2014 Aug 7 [Read here...]
2014
Jin S, Kim J, Willert T, Klein-Rodewald T, Garcia-Dominguez M, Mosqueira M, Fink R, Esposito I, Hofbauer LC, Charnay P, Kieslinger M. Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1. Nat Commun. 2014 May 2;5:3793. doi: 10.1038/ncomms4793. [http://www.ncbi.nlm.nih.gov/pubmed/24786561]
Ehninger A, Boch T, Medyouf H, Müdder K, Orend G, Trumpp A. Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood. 2014; 123: 4054-63. [http://www.ncbi.nlm.nih.gov/pubmed/24833352]
Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014; 15: 227-38. [http://www.ncbi.nlm.nih.gov/pubmed/25017720]
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014; 211: 209-15.[http://www.ncbi.nlm.nih.gov/pubmed/24446490]
Schreck C, Bock F, Grziwok S, Oostendorp RAJ, Istvánffy R. Regulation of hematopoiesis by activators and inhibitors of Wnt signaling from the niche. Ann N Y Acad Sci. 2014; 1310: 32-43.[http://www.ncbi.nlm.nih.gov/pubmed/24611828]